High-grade dysplasia in sporadic fundic gland polyps: a case report and review of the literature

M Jalving, JJ Koornstra, JM Gotz, LA van der Waaij, S de Jong, N Zwart, Arend Karrenbeld, JH Kleibeuker*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

63 Citations (Scopus)

Abstract

We present a case of fundic gland polyps (FGPs) containing high-grade dysplasia in a 68-year-old man. High-grade dysplasia, and even gastric adenocarcinoma, associated with FGPs have been described in patients with familial adenomatous polyposis (FAP) and attenuated familial adenomatous polyposis (AFAP) but never in non-FAP patients. Two colonoscopies in the past six years virtually rule out FAP and AFAP in our patient. Dysplasia in FGPs from non-FAP patients is extremely rare, and until now only cases of low-grade dysplasia have been described. The literature on dysplasia in FGPs is reviewed briefly. Additional immunohistochemical investigations in this case showed nuclear staining of beta-catenin, increased proliferation and apoptosis in the dysplastic areas of the FGPs. Our case suggests that the malignant potential of FGPs is not limited to FAP-associated FGPs. (C) 2003 Lippincott Williams Wilkins.

Original languageEnglish
Pages (from-to)1229-1233
Number of pages5
JournalEuropean journal of gastroenterology & hepatology
Volume15
Issue number11
Publication statusPublished - Nov-2003

Keywords

  • fundic gland polyps
  • dysplasia
  • beta-catenin
  • FAP
  • AFAP
  • FAMILIAL ADENOMATOUS POLYPOSIS
  • UPPER GASTROINTESTINAL POLYPS
  • GASTRIC POLYPS
  • GARDNERS-SYNDROME
  • COLI GENE
  • OMEPRAZOLE
  • MUTATIONS
  • ADENOCARCINOMA
  • THERAPY
  • PATIENT

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