High-grade dysplasia in sporadic fundic gland polyps: A case report and review of the literature

Mathilde Jalving, Jan J. Koornstra, Jan M. Götz, Laurens A. Van Der Waaij, Steven De Jong, Nynke Zwart, Arend Karrenbeld, Jan H. Kleibeuker

Research output: Contribution to journalReview articlepeer-review

Abstract

We present a case of fundic gland polyps (FGPs) containing high-grade dysplasia in a 68-year-old man. High-grade dysplasia, and even gastric adenocarcinoma, associated with FGPs have been described in patients with familial adenomatous polyposis (FAP) and attenuated familial adenomatous polyposis (AFAP) but never in non-FAP patients. Two colonoscopies in the past six years virtually rule out FAP and AFAP in our patient Dysplasia in FGPs from non-FAP patients is extremely rare, and until now only cases of low-grade dysplasia have been described. The literature on dysplasia in FGPs is reviewed briefly. Additional immunohistochemical investigations in this case showed nuclear staining of beta-catenin, increased proliferation and apoptosis in the dysplastic areas of the FGPs. Our case suggests that the malignant potential of FGPs is not limited to FAP-associated FGPs. © 2003 Lippincott Williams & Wilkins.
Original languageEnglish
Pages (from-to)1229-1233
Number of pages5
JournalEuropean journal of gastroenterology & hepatology
Volume15
Issue number11
DOIs
Publication statusPublished - 1-Nov-2003

Keywords

  • AFAP
  • Beta-catenin
  • Dysplasia
  • FAP
  • Fundic gland polyps
  • beta catenin
  • adenomatous polyp
  • aged
  • apoptosis
  • case report
  • cell proliferation
  • clinical feature
  • colonoscopy
  • dysplasia
  • gene expression
  • gene function
  • gene mutation
  • histopathology
  • human
  • immunohistochemistry
  • male
  • priority journal
  • review
  • stomach biopsy
  • stomach fundus
  • stomach polyp

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