High-grade dysplasia in sporadic fundic gland polyps: A case report and review of the literature

Mathilde Jalving, Jan J. Koornstra, Jan M. Götz, Laurens A. Van Der Waaij, Steven De Jong, Nynke Zwart, Arend Karrenbeld, Jan H. Kleibeuker

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We present a case of fundic gland polyps (FGPs) containing high-grade dysplasia in a 68-year-old man. High-grade dysplasia, and even gastric adenocarcinoma, associated with FGPs have been described in patients with familial adenomatous polyposis (FAP) and attenuated familial adenomatous polyposis (AFAP) but never in non-FAP patients. Two colonoscopies in the past six years virtually rule out FAP and AFAP in our patient Dysplasia in FGPs from non-FAP patients is extremely rare, and until now only cases of low-grade dysplasia have been described. The literature on dysplasia in FGPs is reviewed briefly. Additional immunohistochemical investigations in this case showed nuclear staining of beta-catenin, increased proliferation and apoptosis in the dysplastic areas of the FGPs. Our case suggests that the malignant potential of FGPs is not limited to FAP-associated FGPs. © 2003 Lippincott Williams & Wilkins.
Original languageEnglish
Pages (from-to)1229-1233
Number of pages5
JournalEuropean journal of gastroenterology & hepatology
Issue number11
Publication statusPublished - 1-Nov-2003


  • AFAP
  • Beta-catenin
  • Dysplasia
  • FAP
  • Fundic gland polyps
  • beta catenin
  • adenomatous polyp
  • aged
  • apoptosis
  • case report
  • cell proliferation
  • clinical feature
  • colonoscopy
  • dysplasia
  • gene expression
  • gene function
  • gene mutation
  • histopathology
  • human
  • immunohistochemistry
  • male
  • priority journal
  • review
  • stomach biopsy
  • stomach fundus
  • stomach polyp

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