High-Order Epistasis in Catalytic Power of Dihydrofolate Reductase Gives Rise to a Rugged Fitness Landscape in the Presence of Trimethoprim Selection

Yusuf Talha Tamer, Ilona K. Gaszek, Haleh Abdizadeh, Tugce Altinusak Batur, Kimberly A. Reynolds, Ali Rana Atilgan, Canan Atilgan, Erdal Toprak*

*Corresponding author for this work

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Biochemistry, Genetics and Molecular Biology

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