High prevalence of hepatitis G virus after liver transplantation without apparent influence on long-term graft function

EB Haagsma*, HTM Cuypers, ASH Gouw, MC Sjerps, [No Value] Huizenga, MJH Slooff, PLM Jansen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

Abstract

Background/Aims: Hepatitis G virus is a recently characterized transfusion-transmissible RNA virus, Its pathogenicity remains to be established, We studied its prevalence in liver transplant patients and assessed the long-term influence on the liver graft,

Methods: Thirty-nine adult patients without hepatitis B or C were included; median follow-up was 8 years (range 1-17), Serum samples from before and late after transplantation were investigated for the presence of HGV-RNA. HGV-RNA was detected by cDNA-PCR, using primers from the NS3 region of the viral genome. The latest available yearly liver biopsy was assessed in a coded fashion according to established histological criteria, The outcome in the HGV-positive patients was compared with the outcome in the HGV-negative patients with respect to liver tests and liver histology.

Results: The prevalence before and after transplantation was 15.4 and 43.6%, respectively, Liver test results and liver histology did not differ between the HGV and non-HGV groups, In both groups more than 50% of the patients showed normal histology. Mild portal and/or lobular inflammation tended to be more prevalent in the non-HGV group (no statistical difference),

Conclusions: HGV infection is highly prevalent in liver transplant patients, In the absence of co-infection with hepatitis B or C virus, no long-term negative influence on the graft occurs.

Original languageEnglish
Pages (from-to)921-925
Number of pages5
JournalJournal of Hepatology
Volume26
Issue number4
Publication statusPublished - Apr-1997

Keywords

  • hepatitis G virus
  • HGV-RNA
  • liver histology
  • liver transplantation
  • prevalence

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