High short-term effectiveness of modulated dry bed training in adolescents and young adults with treatment-resistant enuresis

I. Hofmeester, J.G.L. Cobussen-Boekhorst, B.B.M. Kortmann, Z. Mulder, M.G. Steffens, W.F.J. Feitz, J.W. Van Capelle, M.H. Blanker

Research output: Contribution to conferenceOtherAcademic

Abstract

Hypothesis/aims of study Two percent of adolescents and adults suffers from enuresis. In this age group, social problems can arise. We evaluated the effect of a Modulated Dry Bed Training (MDBT) in a previously therapy-resistant group of adolescents and adults with enuresis, provided by a specialized enuresis-centre. Study design, materials and methods Descriptive, retrospective cohort study. Between January 2003 and July 2013, 907 patients were treated by MDBT: a 5-days/4- nights in-hospital training in small groups consisting of enuresis-anamnesis, explanation, alarm treatment, day-time activities with the purpose of increasing self-esteem and group contact. We contacted patients by phone during follow-up. Patient data were retrospectively derived from medical files and put in a database. Success of treatment was determined using International Children's Continence Society (ICCS)-definitions, at 6 weeks, 3 and 6 months. Secondary outcome was the medication use after treatment. Sensitivity analyses were performed to control for missing values, and expressed in a best case and a worst case scenario. Results Patients were aged 11-42 years (median 15, IQR 3.5), 34% female. At baseline, 65% had primary enuresis, 81% nonmonosymptomatic enuresis, and 46% frequent enuresis (≥4 days/week). After 6 weeks, 46% (CI95% 43-50) and 41% of patients had a full or partial response, respectively. After 6 months this was 68% (CI95% 65-72) and 25%. Results from the sensitivity analysis are shown in the table. Interpretation of results The treatment response at six months can be considered to be quite high, as this is a formerly therapy-resistant group of enuresis patients. However, the sensitivity analysis shows that, owing to the large amount of missing values, the real number of patients having a full response after six months will lie between 43% and 80%. Concluding message MDBT was shown to have an adequate short term effect in therapy resistant adolescents and adults with enuresis. (Table Presented).
Original languageEnglish
Pages146
Number of pages1
DOIs
Publication statusPublished - 1-Aug-2015

Keywords

  • human
  • young adult
  • enuresis
  • continence
  • society
  • adolescent
  • patient
  • sensitivity analysis
  • therapy
  • adult
  • cohort analysis
  • patient coding
  • follow up
  • study design
  • self esteem
  • anamnesis
  • hospital
  • night
  • social problem
  • data base
  • child
  • treatment response
  • female
  • drug therapy
  • groups by age

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