Highlighting the role of Ras and Rap during Dictyostelium chemotaxis

Arjan Kortholt; Peter J. M. van Haastert

doi:10.1016/j.cellsig.2008.02.006

Highlighting the role of Ras and Rap during Dictyostelium chemotaxis

Arjan Kortholt
, Peter J. M. van Haastert^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

67 Citations (Scopus)

589 Downloads (Pure)

Abstract

Chemotaxis, the directional movement towards a chemical compound, is an essential property of many cells and has been linked to the development and progression of many diseases. Eukaryotic chemotaxis is a complex process involving gradient sensing, cell polarity, remodelling of the cytoskeleton and signal relay. Recent studies in the model organism Dictyostelium discoideum have shown that chemotaxis does not depend on a single molecular mechanism, but rather depends on several interconnecting pathways. Surprisingly, small G-proteins appear to play essential roles in all these pathways. This review will summarize the role of small G-proteins in Dictyostelium, particularly highlighting the function of the Ras subfamily in chemotaxis. (c) 2008 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	1415-1422
Number of pages	8
Journal	Cellular Signalling
Volume	20
Issue number	8
DOIs	https://doi.org/10.1016/j.cellsig.2008.02.006
Publication status	Published - Aug-2008

Keywords

Dictyostelium
chemotaxis
Ras
Rap
guanine exchange factor
GTP-binding protein
RECEPTOR-MEDIATED ACTIVATION
HETEROTRIMERIC G-PROTEINS
CONTROLS CELL-ADHESION
BETA-GAMMA-SUBUNITS
HEAVY-CHAIN KINASE
ADENYLYL-CYCLASE
SIGNAL-TRANSDUCTION
PHOSPHOLIPASE-C
MYOSIN-II
CHEMOATTRACTANT RECEPTORS

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title = "Highlighting the role of Ras and Rap during Dictyostelium chemotaxis",

abstract = "Chemotaxis, the directional movement towards a chemical compound, is an essential property of many cells and has been linked to the development and progression of many diseases. Eukaryotic chemotaxis is a complex process involving gradient sensing, cell polarity, remodelling of the cytoskeleton and signal relay. Recent studies in the model organism Dictyostelium discoideum have shown that chemotaxis does not depend on a single molecular mechanism, but rather depends on several interconnecting pathways. Surprisingly, small G-proteins appear to play essential roles in all these pathways. This review will summarize the role of small G-proteins in Dictyostelium, particularly highlighting the function of the Ras subfamily in chemotaxis. (c) 2008 Elsevier Inc. All rights reserved.",

keywords = "Dictyostelium, chemotaxis, Ras, Rap, guanine exchange factor, GTP-binding protein, RECEPTOR-MEDIATED ACTIVATION, HETEROTRIMERIC G-PROTEINS, CONTROLS CELL-ADHESION, BETA-GAMMA-SUBUNITS, HEAVY-CHAIN KINASE, ADENYLYL-CYCLASE, SIGNAL-TRANSDUCTION, PHOSPHOLIPASE-C, MYOSIN-II, CHEMOATTRACTANT RECEPTORS",

author = "Arjan Kortholt and \{van Haastert\}, \{Peter J. M.\}",

year = "2008",

month = aug,

doi = "10.1016/j.cellsig.2008.02.006",

language = "English",

volume = "20",

pages = "1415--1422",

journal = "Cellular Signalling",

issn = "0898-6568",

publisher = "ELSEVIER SCIENCE INC",

number = "8",

}

TY - JOUR

T1 - Highlighting the role of Ras and Rap during Dictyostelium chemotaxis

AU - Kortholt, Arjan

AU - van Haastert, Peter J. M.

PY - 2008/8

Y1 - 2008/8

N2 - Chemotaxis, the directional movement towards a chemical compound, is an essential property of many cells and has been linked to the development and progression of many diseases. Eukaryotic chemotaxis is a complex process involving gradient sensing, cell polarity, remodelling of the cytoskeleton and signal relay. Recent studies in the model organism Dictyostelium discoideum have shown that chemotaxis does not depend on a single molecular mechanism, but rather depends on several interconnecting pathways. Surprisingly, small G-proteins appear to play essential roles in all these pathways. This review will summarize the role of small G-proteins in Dictyostelium, particularly highlighting the function of the Ras subfamily in chemotaxis. (c) 2008 Elsevier Inc. All rights reserved.

AB - Chemotaxis, the directional movement towards a chemical compound, is an essential property of many cells and has been linked to the development and progression of many diseases. Eukaryotic chemotaxis is a complex process involving gradient sensing, cell polarity, remodelling of the cytoskeleton and signal relay. Recent studies in the model organism Dictyostelium discoideum have shown that chemotaxis does not depend on a single molecular mechanism, but rather depends on several interconnecting pathways. Surprisingly, small G-proteins appear to play essential roles in all these pathways. This review will summarize the role of small G-proteins in Dictyostelium, particularly highlighting the function of the Ras subfamily in chemotaxis. (c) 2008 Elsevier Inc. All rights reserved.

KW - Dictyostelium

KW - chemotaxis

KW - Ras

KW - Rap

KW - guanine exchange factor

KW - GTP-binding protein

KW - RECEPTOR-MEDIATED ACTIVATION

KW - HETEROTRIMERIC G-PROTEINS

KW - CONTROLS CELL-ADHESION

KW - BETA-GAMMA-SUBUNITS

KW - HEAVY-CHAIN KINASE

KW - ADENYLYL-CYCLASE

KW - SIGNAL-TRANSDUCTION

KW - PHOSPHOLIPASE-C

KW - MYOSIN-II

KW - CHEMOATTRACTANT RECEPTORS

U2 - 10.1016/j.cellsig.2008.02.006

DO - 10.1016/j.cellsig.2008.02.006

M3 - Review article

SN - 0898-6568

VL - 20

SP - 1415

EP - 1422

JO - Cellular Signalling

JF - Cellular Signalling

IS - 8

ER -

Highlighting the role of Ras and Rap during Dictyostelium chemotaxis

Abstract

Keywords

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