Highly Efficient Antimicrobial and Antifouling Surface Coatings with Triclosan-Loaded Nanogels

Damla Keskin, Lisa Tromp, Olga Mergel, Guangyue Zu, Eliza Warszawik, Henny C. van der Mei, Patrick van Rijn*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
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Abstract

Multifunctional nanogel coatings provide a promising antimicrobial strategy against biomedical implant-associated infections. Nanogels can create a hydrated surface layer to promote antifouling properties effectively. Further modification of nanogels with quaternary ammonium compounds (QACs) potentiates antimicrobial activity owing to their positive charges along with the presence of a membrane-intercalating alkyl chain. This study effectively demonstrates that poly(N-isopropylacrylamide-coN-[3(dimethylamino)propyl]methacrylamide) (P(NIPAM-co-DMAPMA)-based nanogel coatings possess antifouling behavior against S. aureus ATCC 12600, a Gram-positive bacterium. Through the tertiary amine in the DMAPMA comonomer, nanogels are quaternized with a 1-bromo-dodecane chain via an N-alkylation reaction. The alkylation introduces the antibacterial activity due to the bacterial membrane binding and the intercalating ability of the aliphatic QAC. Subsequently, the quaternized nanogels enable the formation of intraparticle hydrophobic domains because of intraparticle hydrophobic interactions of the aliphatic chains allowing for Triclosan incorporation. The coating with Triclosan-loaded nanogels shows a killing efficacy of up to 99.99% of adhering bacteria on the surface compared to nonquaternized nanogel coatings while still possessing an antifouling activity. This powerful multifunctional coating for combating biomaterial-associated infection is envisioned to greatly impact the design approaches for future clinically applied coatings.

Original languageEnglish
Pages (from-to)57721-57731
Number of pages11
JournalACS Applied Materials & Interfaces
Volume12
Issue number52
DOIs
Publication statusPublished - 30-Dec-2020

Keywords

  • Nanogels
  • bacterial adhesion
  • killing efficacy
  • drug delivery
  • quaternization
  • MICROBIAL ADHESION
  • MICROGEL FILMS
  • BIOFILM
  • RESISTANCE
  • ADSORPTION
  • STABILITY
  • MICELLES
  • DELIVERY
  • BEHAVIOR
  • PH

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