Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes

T den Heijer; M Oudkerk; LJ Launer; CM van Duijn; A Hofman; MMB Breteler

Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes

T den Heijer, M Oudkerk, LJ Launer, CM van Duijn, A Hofman, MMB Breteler^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

159 Citations (Scopus)

Abstract

The epsilon4 allele of the APOE gene increases the risk for AD, whereas the epsilon2 allele may be protective. The authors assessed the impact of APOE genotype on hippocampal, amygdalar, and global brain atrophy as putative markers of preclinical AD in a nondemented population. Carriers Of epsilon4 had significantly more hippocampal and amygdalar atrophy than epsilon3epsilon3 subjects, but not more global brain atrophy. Carriers of epsilon2 did not have less brain atrophy than epsilon3epsilon3 subjects.

Original language	English
Pages (from-to)	746-748
Number of pages	3
Journal	Neurology
Volume	59
Issue number	5
Publication status	Published - 10-Sept-2002

Keywords

E EPSILON-4
ALZHEIMERS-DISEASE
DEMENTIA
ALLELE
ROTTERDAM
LOBE

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@article{61ecf47447dd4d5bbc4ac168e56f4149,

title = "Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes",

abstract = "The epsilon4 allele of the APOE gene increases the risk for AD, whereas the epsilon2 allele may be protective. The authors assessed the impact of APOE genotype on hippocampal, amygdalar, and global brain atrophy as putative markers of preclinical AD in a nondemented population. Carriers Of epsilon4 had significantly more hippocampal and amygdalar atrophy than epsilon3epsilon3 subjects, but not more global brain atrophy. Carriers of epsilon2 did not have less brain atrophy than epsilon3epsilon3 subjects.",

keywords = "E EPSILON-4, ALZHEIMERS-DISEASE, DEMENTIA, ALLELE, ROTTERDAM, LOBE",

author = "{den Heijer}, T and M Oudkerk and LJ Launer and {van Duijn}, CM and A Hofman and MMB Breteler",

year = "2002",

month = sep,

day = "10",

language = "English",

volume = "59",

pages = "746--748",

journal = "Neurology",

issn = "0028-3878",

publisher = "LIPPINCOTT WILLIAMS & WILKINS",

number = "5",

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TY - JOUR

T1 - Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes

AU - den Heijer, T

AU - Oudkerk, M

AU - Launer, LJ

AU - van Duijn, CM

AU - Hofman, A

AU - Breteler, MMB

PY - 2002/9/10

Y1 - 2002/9/10

N2 - The epsilon4 allele of the APOE gene increases the risk for AD, whereas the epsilon2 allele may be protective. The authors assessed the impact of APOE genotype on hippocampal, amygdalar, and global brain atrophy as putative markers of preclinical AD in a nondemented population. Carriers Of epsilon4 had significantly more hippocampal and amygdalar atrophy than epsilon3epsilon3 subjects, but not more global brain atrophy. Carriers of epsilon2 did not have less brain atrophy than epsilon3epsilon3 subjects.

AB - The epsilon4 allele of the APOE gene increases the risk for AD, whereas the epsilon2 allele may be protective. The authors assessed the impact of APOE genotype on hippocampal, amygdalar, and global brain atrophy as putative markers of preclinical AD in a nondemented population. Carriers Of epsilon4 had significantly more hippocampal and amygdalar atrophy than epsilon3epsilon3 subjects, but not more global brain atrophy. Carriers of epsilon2 did not have less brain atrophy than epsilon3epsilon3 subjects.

KW - E EPSILON-4

KW - ALZHEIMERS-DISEASE

KW - DEMENTIA

KW - ALLELE

KW - ROTTERDAM

KW - LOBE

M3 - Article

SN - 0028-3878

VL - 59

SP - 746

EP - 748

JO - Neurology

JF - Neurology

IS - 5

ER -

Hippocampal, amygdalar, and global brain atrophy in different apolipoprotein E genotypes

Abstract

Keywords

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