Histone acetyltransferases are crucial regulators in NF-kappa B mediated inflammation

Massimo Ghizzoni, Hidde J. Haisma, Harm Maarsingh, Frank J. Dekker*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

90 Citations (Scopus)

Abstract

Post-translational modifications of proteins, such as acetylation, are important regulatory events in eukaryotic cells. Reversible acetylations of histones and non-histone proteins regulate gene expression and protein activity. Acetylation levels of proteins are regulated by a dynamic equilibrium between acetylation by (histone) acetyltransferases and deacetylation by (histone) deacetylases. Alterations in this equilibrium can result in pathological states. Inflammation is a physiological response that, under certain conditions, turns into a disease. This review focuses on the crucial regulatory roles of protein acetylation in NF-kappa B-mediated inflammation and the potential applications of small-molecule inhibitors of acetylation for the treatment of inflammatory diseases.

Original languageEnglish
Pages (from-to)504-511
Number of pages8
JournalDrug Discovery Today
Volume16
Issue number11-12
DOIs
Publication statusPublished - Jun-2011

Keywords

  • DEPENDENT GENE-EXPRESSION
  • CREB-BINDING PROTEIN
  • SMOOTH-MUSCLE-CELLS
  • H4 ACETYLATION
  • ANACARDIC ACID
  • IN-VIVO
  • TRANSCRIPTIONAL ACTIVATION
  • CHROMATIN TRANSCRIPTION
  • DEACETYLASE ACTIVITY
  • LUNG INFLAMMATION

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