Histone acetyltransferases are crucial regulators in NF-kappa B mediated inflammation

Massimo Ghizzoni; Hidde J. Haisma; Harm Maarsingh; Frank J. Dekker

doi:10.1016/j.drudis.2011.03.009

Histone acetyltransferases are crucial regulators in NF-kappa B mediated inflammation

Massimo Ghizzoni, Hidde J. Haisma, Harm Maarsingh, Frank J. Dekker^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

117 Citations (Scopus)

Abstract

Post-translational modifications of proteins, such as acetylation, are important regulatory events in eukaryotic cells. Reversible acetylations of histones and non-histone proteins regulate gene expression and protein activity. Acetylation levels of proteins are regulated by a dynamic equilibrium between acetylation by (histone) acetyltransferases and deacetylation by (histone) deacetylases. Alterations in this equilibrium can result in pathological states. Inflammation is a physiological response that, under certain conditions, turns into a disease. This review focuses on the crucial regulatory roles of protein acetylation in NF-kappa B-mediated inflammation and the potential applications of small-molecule inhibitors of acetylation for the treatment of inflammatory diseases.

Original language	English
Pages (from-to)	504-511
Number of pages	8
Journal	Drug Discovery Today
Volume	16
Issue number	11-12
DOIs	https://doi.org/10.1016/j.drudis.2011.03.009
Publication status	Published - Jun-2011

Keywords

DEPENDENT GENE-EXPRESSION
CREB-BINDING PROTEIN
SMOOTH-MUSCLE-CELLS
H4 ACETYLATION
ANACARDIC ACID
IN-VIVO
TRANSCRIPTIONAL ACTIVATION
CHROMATIN TRANSCRIPTION
DEACETYLASE ACTIVITY
LUNG INFLAMMATION

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title = "Histone acetyltransferases are crucial regulators in NF-kappa B mediated inflammation",

abstract = "Post-translational modifications of proteins, such as acetylation, are important regulatory events in eukaryotic cells. Reversible acetylations of histones and non-histone proteins regulate gene expression and protein activity. Acetylation levels of proteins are regulated by a dynamic equilibrium between acetylation by (histone) acetyltransferases and deacetylation by (histone) deacetylases. Alterations in this equilibrium can result in pathological states. Inflammation is a physiological response that, under certain conditions, turns into a disease. This review focuses on the crucial regulatory roles of protein acetylation in NF-kappa B-mediated inflammation and the potential applications of small-molecule inhibitors of acetylation for the treatment of inflammatory diseases.",

keywords = "DEPENDENT GENE-EXPRESSION, CREB-BINDING PROTEIN, SMOOTH-MUSCLE-CELLS, H4 ACETYLATION, ANACARDIC ACID, IN-VIVO, TRANSCRIPTIONAL ACTIVATION, CHROMATIN TRANSCRIPTION, DEACETYLASE ACTIVITY, LUNG INFLAMMATION",

author = "Massimo Ghizzoni and Haisma, {Hidde J.} and Harm Maarsingh and Dekker, {Frank J.}",

year = "2011",

month = jun,

doi = "10.1016/j.drudis.2011.03.009",

language = "English",

volume = "16",

pages = "504--511",

journal = "Drug Discovery Today",

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TY - JOUR

T1 - Histone acetyltransferases are crucial regulators in NF-kappa B mediated inflammation

AU - Ghizzoni, Massimo

AU - Haisma, Hidde J.

AU - Maarsingh, Harm

AU - Dekker, Frank J.

PY - 2011/6

Y1 - 2011/6

N2 - Post-translational modifications of proteins, such as acetylation, are important regulatory events in eukaryotic cells. Reversible acetylations of histones and non-histone proteins regulate gene expression and protein activity. Acetylation levels of proteins are regulated by a dynamic equilibrium between acetylation by (histone) acetyltransferases and deacetylation by (histone) deacetylases. Alterations in this equilibrium can result in pathological states. Inflammation is a physiological response that, under certain conditions, turns into a disease. This review focuses on the crucial regulatory roles of protein acetylation in NF-kappa B-mediated inflammation and the potential applications of small-molecule inhibitors of acetylation for the treatment of inflammatory diseases.

AB - Post-translational modifications of proteins, such as acetylation, are important regulatory events in eukaryotic cells. Reversible acetylations of histones and non-histone proteins regulate gene expression and protein activity. Acetylation levels of proteins are regulated by a dynamic equilibrium between acetylation by (histone) acetyltransferases and deacetylation by (histone) deacetylases. Alterations in this equilibrium can result in pathological states. Inflammation is a physiological response that, under certain conditions, turns into a disease. This review focuses on the crucial regulatory roles of protein acetylation in NF-kappa B-mediated inflammation and the potential applications of small-molecule inhibitors of acetylation for the treatment of inflammatory diseases.

KW - DEPENDENT GENE-EXPRESSION

KW - CREB-BINDING PROTEIN

KW - SMOOTH-MUSCLE-CELLS

KW - H4 ACETYLATION

KW - ANACARDIC ACID

KW - IN-VIVO

KW - TRANSCRIPTIONAL ACTIVATION

KW - CHROMATIN TRANSCRIPTION

KW - DEACETYLASE ACTIVITY

KW - LUNG INFLAMMATION

U2 - 10.1016/j.drudis.2011.03.009

DO - 10.1016/j.drudis.2011.03.009

M3 - Review article

SN - 1359-6446

VL - 16

SP - 504

EP - 511

JO - Drug Discovery Today

JF - Drug Discovery Today

IS - 11-12

ER -

Histone acetyltransferases are crucial regulators in NF-kappa B mediated inflammation

Abstract

Keywords

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