Histone variants and lipid metabolism

Michela Borghesan; Gianluigi Mazzoccoli; Fareeba Sheedfar; Jude Oben; Valerio Pazienza; Manlio Vinciguerra

doi:10.1042/BST20140119

Histone variants and lipid metabolism

Michela Borghesan, Gianluigi Mazzoccoli, Fareeba Sheedfar, Jude Oben, Valerio Pazienza^*, Manlio Vinciguerra

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

10 Citations (Scopus)

Abstract

Within nucleosomes, canonical histones package the genome, but they can be opportunely replaced with histone variants. The incorporation of histone variants into the nucleosome is a chief cellular strategy to regulate transcription and cellular metabolism. In pathological terms, cellular steatosis is an abnormal accumulation of lipids, which reflects impairment in the turnover of triacylglycerols, affecting any organ but mainly the liver. The present review aims to summarize the experimental evidence for histone variant functions in lipid metabolism.

Original language	English
Pages (from-to)	1409-1413
Number of pages	5
Journal	Biochemical Society Transactions
Volume	42
DOIs	https://doi.org/10.1042/BST20140119
Publication status	Published - Oct-2014

Keywords

gene expression
histone variant
lipid metabolism
nucleosome
steatosis
FATTY LIVER-DISEASE
HEPATIC STEATOSIS
MATERNAL OBESITY
CHROMATIN
GENOME
MICE
H3.3
EPIGENETICS
MACROH2A1
BINDING

Access to Document

10.1042/BST20140119

Cite this

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title = "Histone variants and lipid metabolism",

abstract = "Within nucleosomes, canonical histones package the genome, but they can be opportunely replaced with histone variants. The incorporation of histone variants into the nucleosome is a chief cellular strategy to regulate transcription and cellular metabolism. In pathological terms, cellular steatosis is an abnormal accumulation of lipids, which reflects impairment in the turnover of triacylglycerols, affecting any organ but mainly the liver. The present review aims to summarize the experimental evidence for histone variant functions in lipid metabolism.",

keywords = "gene expression, histone variant, lipid metabolism, nucleosome, steatosis, FATTY LIVER-DISEASE, HEPATIC STEATOSIS, MATERNAL OBESITY, CHROMATIN, GENOME, MICE, H3.3, EPIGENETICS, MACROH2A1, BINDING",

author = "Michela Borghesan and Gianluigi Mazzoccoli and Fareeba Sheedfar and Jude Oben and Valerio Pazienza and Manlio Vinciguerra",

year = "2014",

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doi = "10.1042/BST20140119",

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pages = "1409--1413",

journal = "Biochemical Society Transactions",

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TY - JOUR

T1 - Histone variants and lipid metabolism

AU - Borghesan, Michela

AU - Mazzoccoli, Gianluigi

AU - Sheedfar, Fareeba

AU - Oben, Jude

AU - Pazienza, Valerio

AU - Vinciguerra, Manlio

PY - 2014/10

Y1 - 2014/10

N2 - Within nucleosomes, canonical histones package the genome, but they can be opportunely replaced with histone variants. The incorporation of histone variants into the nucleosome is a chief cellular strategy to regulate transcription and cellular metabolism. In pathological terms, cellular steatosis is an abnormal accumulation of lipids, which reflects impairment in the turnover of triacylglycerols, affecting any organ but mainly the liver. The present review aims to summarize the experimental evidence for histone variant functions in lipid metabolism.

AB - Within nucleosomes, canonical histones package the genome, but they can be opportunely replaced with histone variants. The incorporation of histone variants into the nucleosome is a chief cellular strategy to regulate transcription and cellular metabolism. In pathological terms, cellular steatosis is an abnormal accumulation of lipids, which reflects impairment in the turnover of triacylglycerols, affecting any organ but mainly the liver. The present review aims to summarize the experimental evidence for histone variant functions in lipid metabolism.

KW - gene expression

KW - histone variant

KW - lipid metabolism

KW - nucleosome

KW - steatosis

KW - FATTY LIVER-DISEASE

KW - HEPATIC STEATOSIS

KW - MATERNAL OBESITY

KW - CHROMATIN

KW - GENOME

KW - MICE

KW - H3.3

KW - EPIGENETICS

KW - MACROH2A1

KW - BINDING

U2 - 10.1042/BST20140119

DO - 10.1042/BST20140119

M3 - Article

VL - 42

SP - 1409

EP - 1413

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 0300-5127

ER -