Histone variants and lipid metabolism

Michela Borghesan, Gianluigi Mazzoccoli, Fareeba Sheedfar, Jude Oben, Valerio Pazienza*, Manlio Vinciguerra

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    10 Citations (Scopus)

    Abstract

    Within nucleosomes, canonical histones package the genome, but they can be opportunely replaced with histone variants. The incorporation of histone variants into the nucleosome is a chief cellular strategy to regulate transcription and cellular metabolism. In pathological terms, cellular steatosis is an abnormal accumulation of lipids, which reflects impairment in the turnover of triacylglycerols, affecting any organ but mainly the liver. The present review aims to summarize the experimental evidence for histone variant functions in lipid metabolism.

    Original languageEnglish
    Pages (from-to)1409-1413
    Number of pages5
    JournalBiochemical Society Transactions
    Volume42
    DOIs
    Publication statusPublished - Oct-2014

    Keywords

    • gene expression
    • histone variant
    • lipid metabolism
    • nucleosome
    • steatosis
    • FATTY LIVER-DISEASE
    • HEPATIC STEATOSIS
    • MATERNAL OBESITY
    • CHROMATIN
    • GENOME
    • MICE
    • H3.3
    • EPIGENETICS
    • MACROH2A1
    • BINDING

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