History, challenges and perspectives of cell microencapsulation

G. Orive; R.M. Hernandez; A.R. Gascon; R. Calafiore; T.M.S. Chang; P. de Vos; G. Hortelano; D. Hunkeler; I. Lacik; J.L. Pedraz

doi:10.1016/j.tibtech.2003.11.004

History, challenges and perspectives of cell microencapsulation

G. Orive
, R.M. Hernandez
, A.R. Gascon
, R. Calafiore
, T.M.S. Chang
, P. de Vos
, G. Hortelano
, D. Hunkeler
, I. Lacik
, J.L. Pedraz^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

340 Citations (Scopus)

Abstract

Cell microencapsulation continues to hold significant promise for biotechnology and medicine. The controlled, and continuous, delivery of therapeutic products to the host by immunoisolated cells is a potentially cost-effective method to treat a wide range of diseases. Although there are several issues that need to be addressed, including capsule manufacture, properties and performance, in the past few years, a stepwise analysis on the essential obstacles and limitations has brought the whole technology closer to a realistic proposal for clinical application. This paper summarizes the current situation in the cell encapsulation field and discusses the main events that have occurred along the way.

Original language	Dutch
Pages (from-to)	87-92
Number of pages	6
Journal	Trends in Biotechnology
Volume	22
Issue number	2
DOIs	https://doi.org/10.1016/j.tibtech.2003.11.004
Publication status	Published - 2004

Keywords

PANCREATIC-ISLETS
ALGINATE MICROCAPSULES
ENDOCRINE PANCREAS
PORCINE ISLETS
GENE-THERAPY
TRANSPLANTATION
IMMUNOISOLATION
ENCAPSULATION
IMMUNOSUPPRESSION
BIOCOMPATIBILITY

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title = "History, challenges and perspectives of cell microencapsulation",

abstract = "Cell microencapsulation continues to hold significant promise for biotechnology and medicine. The controlled, and continuous, delivery of therapeutic products to the host by immunoisolated cells is a potentially cost-effective method to treat a wide range of diseases. Although there are several issues that need to be addressed, including capsule manufacture, properties and performance, in the past few years, a stepwise analysis on the essential obstacles and limitations has brought the whole technology closer to a realistic proposal for clinical application. This paper summarizes the current situation in the cell encapsulation field and discusses the main events that have occurred along the way.",

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AU - Orive, G.

AU - Hernandez, R.M.

AU - Gascon, A.R.

AU - Calafiore, R.

AU - Chang, T.M.S.

AU - de Vos, P.

AU - Hortelano, G.

AU - Hunkeler, D.

AU - Lacik, I.

AU - Pedraz, J.L.

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AB - Cell microencapsulation continues to hold significant promise for biotechnology and medicine. The controlled, and continuous, delivery of therapeutic products to the host by immunoisolated cells is a potentially cost-effective method to treat a wide range of diseases. Although there are several issues that need to be addressed, including capsule manufacture, properties and performance, in the past few years, a stepwise analysis on the essential obstacles and limitations has brought the whole technology closer to a realistic proposal for clinical application. This paper summarizes the current situation in the cell encapsulation field and discusses the main events that have occurred along the way.

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KW - ALGINATE MICROCAPSULES

KW - ENDOCRINE PANCREAS

KW - PORCINE ISLETS

KW - GENE-THERAPY

KW - TRANSPLANTATION

KW - IMMUNOISOLATION

KW - ENCAPSULATION

KW - IMMUNOSUPPRESSION

KW - BIOCOMPATIBILITY

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