HIV Infection Is Associated with a Preferential Decline in Less-Differentiated CD56(dim) CD16(+) NK Cells

Henoch S. Hong, Johanna M. Eberhard, Phillip Keudel, Benjamin A. Bollmann, Matthias Ballmaier, Nupur Bhatnagar, Margot Zielinska-Skowronek, Reinhold E. Schmidt, Dirk Meyer-Olson*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

56 Citations (Scopus)

Abstract

HIV-1 infection is characterized by loss of CD56(dim) CD16(+) NK cells and increased terminal differentiation on various lymphocyte subsets. We identified a decrease of CD57(+) and CD57(dim) cells but not of CD57(bright) cells on CD56dim CD16(+) NK cells in chronic HIV infection. Increasing CD57 expression was strongly associated with increasing frequencies of killer immunoglobulin-like receptors (KIRs) and granzyme B-expressing cells but decreasing percentages of cells expressing CD27(+), HLA-DR+, Ki-67(+), and CD107a. Our data indicate that HIV leads to a decline of less-differentiated cells and suggest that CD57 is a useful marker for terminal differentiation on NK cells.

Original languageEnglish
Pages (from-to)1183-1188
Number of pages6
JournalJournal of Virology
Volume84
Issue number2
DOIs
Publication statusPublished - 15-Jan-2010

Keywords

  • NATURAL-KILLER-CELLS
  • HLA-B
  • RECEPTOR
  • PROGRESSION
  • REPERTOIRE
  • EXPRESSION
  • DIVERSITY
  • RESPONSES
  • SUBSETS
  • VIREMIA

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