HLA class II alleles of susceptibility and protection in Brazilian and Dutch pemphigus foliaceus

L de Sena Nogueira Maehara; F C De-Souza-Santana; A M Porro; E V C Marcos; S Ura; I M Nolte; H H Pas; M F Jonkman; J Tomimori

doi:10.1111/bjd.16022

HLA class II alleles of susceptibility and protection in Brazilian and Dutch pemphigus foliaceus

L de Sena Nogueira Maehara, F C De-Souza-Santana, A M Porro, E V C Marcos, S Ura, I M Nolte, H H Pas, M F Jonkman, J Tomimori

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

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Abstract

Pemphigus foliaceus (PF) is a worldwide chronic autoimmune bullous disease targeting desmoglein 1 (Dsg 1) on epithelial cell surface of skin and mucous membranes, causing lesions in skin but sparing mucosa, since the latter contain compensating desmoglein 3(1) . Several environmental triggers for the autoimmune reaction have been imputed, such as drugs, ultraviolet radiation and mercurium. Human leucocyte antigens class II (HLA-DR4) alleles were linked to the disease in Ashkenazi Jews and other populations(2) . For endemic pemphigus foliaceus in Brazil, named fogo selvagem (FS), HLA-DRB1*04 was shown to have a relative risk >14 for the disease(3) . This article is protected by copyright. All rights reserved.

Original language	English
Pages (from-to)	e212-e214
Number of pages	3
Journal	The British journal of dermatology
Volume	178
Issue number	3
DOIs	https://doi.org/10.1111/bjd.16022
Publication status	Published - Mar-2018

Keywords

Letter
VULGARIS
GENETICS
FOGO-SELVAGEM

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HLA class II alleles of susceptibility and protection in Brazilian Final publisher's version, 70.7 KBLicence: Taverne

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@article{554c615a824043da8eb4e1023f636eea,

title = "HLA class II alleles of susceptibility and protection in Brazilian and Dutch pemphigus foliaceus",

abstract = "Pemphigus foliaceus (PF) is a worldwide chronic autoimmune bullous disease targeting desmoglein 1 (Dsg 1) on epithelial cell surface of skin and mucous membranes, causing lesions in skin but sparing mucosa, since the latter contain compensating desmoglein 3(1) . Several environmental triggers for the autoimmune reaction have been imputed, such as drugs, ultraviolet radiation and mercurium. Human leucocyte antigens class II (HLA-DR4) alleles were linked to the disease in Ashkenazi Jews and other populations(2) . For endemic pemphigus foliaceus in Brazil, named fogo selvagem (FS), HLA-DRB1*04 was shown to have a relative risk >14 for the disease(3) . This article is protected by copyright. All rights reserved.",

keywords = "Letter, VULGARIS, GENETICS, FOGO-SELVAGEM",

author = "{de Sena Nogueira Maehara}, L and De-Souza-Santana, {F C} and Porro, {A M} and Marcos, {E V C} and S Ura and Nolte, {I M} and Pas, {H H} and Jonkman, {M F} and J Tomimori",

year = "2018",

month = mar,

doi = "10.1111/bjd.16022",

language = "English",

volume = "178",

pages = "e212--e214",

journal = "The British journal of dermatology",

issn = "0007-0963",

publisher = "Wiley",

number = "3",

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TY - JOUR

T1 - HLA class II alleles of susceptibility and protection in Brazilian and Dutch pemphigus foliaceus

AU - de Sena Nogueira Maehara, L

AU - De-Souza-Santana, F C

AU - Porro, A M

AU - Marcos, E V C

AU - Ura, S

AU - Nolte, I M

AU - Pas, H H

AU - Jonkman, M F

AU - Tomimori, J

PY - 2018/3

Y1 - 2018/3

N2 - Pemphigus foliaceus (PF) is a worldwide chronic autoimmune bullous disease targeting desmoglein 1 (Dsg 1) on epithelial cell surface of skin and mucous membranes, causing lesions in skin but sparing mucosa, since the latter contain compensating desmoglein 3(1) . Several environmental triggers for the autoimmune reaction have been imputed, such as drugs, ultraviolet radiation and mercurium. Human leucocyte antigens class II (HLA-DR4) alleles were linked to the disease in Ashkenazi Jews and other populations(2) . For endemic pemphigus foliaceus in Brazil, named fogo selvagem (FS), HLA-DRB1*04 was shown to have a relative risk >14 for the disease(3) . This article is protected by copyright. All rights reserved.

AB - Pemphigus foliaceus (PF) is a worldwide chronic autoimmune bullous disease targeting desmoglein 1 (Dsg 1) on epithelial cell surface of skin and mucous membranes, causing lesions in skin but sparing mucosa, since the latter contain compensating desmoglein 3(1) . Several environmental triggers for the autoimmune reaction have been imputed, such as drugs, ultraviolet radiation and mercurium. Human leucocyte antigens class II (HLA-DR4) alleles were linked to the disease in Ashkenazi Jews and other populations(2) . For endemic pemphigus foliaceus in Brazil, named fogo selvagem (FS), HLA-DRB1*04 was shown to have a relative risk >14 for the disease(3) . This article is protected by copyright. All rights reserved.

KW - Letter

KW - VULGARIS

KW - GENETICS

KW - FOGO-SELVAGEM

U2 - 10.1111/bjd.16022

DO - 10.1111/bjd.16022

M3 - Comment/Letter to the editor

C2 - 28977698

SN - 0007-0963

VL - 178

SP - e212-e214

JO - The British journal of dermatology

JF - The British journal of dermatology

IS - 3

ER -

HLA class II alleles of susceptibility and protection in Brazilian and Dutch pemphigus foliaceus

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