Honey, I Shrunk the DNA: DNA Length as a Probe for Nucleic-Acid Enzyme Activity

Antoine M. van Oijen

doi:10.1002/bip.20624

Honey, I Shrunk the DNA: DNA Length as a Probe for Nucleic-Acid Enzyme Activity

Antoine M. van Oijen

Zernike Institute for Advanced Materials

Research output: Contribution to journal › Article › Academic

28 Citations (Scopus)

266 Downloads (Pure)

Abstract

The replication, recombination, and repair of DNA are processes essential for the maintenance of genomic information and require the activity of numerous enzymes that catalyze the polymerization or digestion of DNA. This review will discuss how differences in elastic properties between single- and double-stranded DNA can be used as a probe to study the dynamics of these enzymes at the single-molecule level.

Original language	English
Pages (from-to)	144-153
Number of pages	10
Journal	Biopolymers
Volume	85
Issue number	2
DOIs	https://doi.org/10.1002/bip.20624
Publication status	Published - 2007

Keywords

replication
nuclease
polymerase
DNA
single-molecule

Access to Document

10.1002/bip.20624

2007BiopolymersvOijen.pdfFinal publisher's version, 288 KB

Handle.net

Persistent link

Cite this

@article{27bbc6efc5b04cdebc92003494abb956,

title = "Honey, I Shrunk the DNA: DNA Length as a Probe for Nucleic-Acid Enzyme Activity",

abstract = "The replication, recombination, and repair of DNA are processes essential for the maintenance of genomic information and require the activity of numerous enzymes that catalyze the polymerization or digestion of DNA. This review will discuss how differences in elastic properties between single- and double-stranded DNA can be used as a probe to study the dynamics of these enzymes at the single-molecule level.",

keywords = "replication, nuclease, polymerase, DNA, single-molecule",

author = "Oijen, \{Antoine M. van\}",

note = "Relation: http://www.rug.nl/zernike/ Rights: University of Groningen, Zernike Institute for Advanced Materials",

year = "2007",

doi = "10.1002/bip.20624",

language = "English",

volume = "85",

pages = "144--153",

journal = "Biopolymers",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - Honey, I Shrunk the DNA

T2 - DNA Length as a Probe for Nucleic-Acid Enzyme Activity

AU - Oijen, Antoine M. van

N1 - Relation: http://www.rug.nl/zernike/ Rights: University of Groningen, Zernike Institute for Advanced Materials

PY - 2007

Y1 - 2007

N2 - The replication, recombination, and repair of DNA are processes essential for the maintenance of genomic information and require the activity of numerous enzymes that catalyze the polymerization or digestion of DNA. This review will discuss how differences in elastic properties between single- and double-stranded DNA can be used as a probe to study the dynamics of these enzymes at the single-molecule level.

AB - The replication, recombination, and repair of DNA are processes essential for the maintenance of genomic information and require the activity of numerous enzymes that catalyze the polymerization or digestion of DNA. This review will discuss how differences in elastic properties between single- and double-stranded DNA can be used as a probe to study the dynamics of these enzymes at the single-molecule level.

KW - replication

KW - nuclease

KW - polymerase

KW - DNA

KW - single-molecule

U2 - 10.1002/bip.20624

DO - 10.1002/bip.20624

M3 - Article

VL - 85

SP - 144

EP - 153

JO - Biopolymers

JF - Biopolymers

IS - 2

ER -

Honey, I Shrunk the DNA: DNA Length as a Probe for Nucleic-Acid Enzyme Activity

Abstract

Keywords

Access to Document

Handle.net

Fingerprint

Cite this