Hormone receptors as a marker of poor survival in epithelial ovarian cancer

Michel van Kruchten*, Pauline van der Marel, Linda de Munck, Harry Hollema, Henriette Arts, Hetty Timmer-Bosscha, Elisabeth G. E. de Vries, Geke Hospers, Anna Reyners

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

30 Citations (Scopus)

Abstract

Objective. Androgen receptor (AR), estrogen receptor alpha and beta (ER alpha, ER beta), and progesterone receptor (PR) are potential therapeutic targets in epithelial ovarian cancer. In this study we evaluate the prognostic value of these hormone receptors in ovarian cancer patients.

Methods. In a prospective multicenter randomized controlled phase II trial 196 ovarian cancer patients were randomized to carboplatin/docetaxel celecoxib +/- Of 121 patients sufficient tumor tissue was available for hormone receptor analysis. Tissue micro-arrays were stained for AR, ER alpha, ER beta, and PR. Cluster analysis was performed to identify subgroups based on hormone receptor expression profile. Receptor expression was correlated to progression-free survival (PFS) and overall survival (OS) in uni- and multivariate analysis.

Results. AR, ER alpha, ER beta, and PR were expressed in respectively 10%, 31%, 73%, and 19%. In patients with synchronous metastasis tissue available (n = 69 patients), discordant receptor expression was observed in 9-32%. ER beta-expression was associated with poor PFS and OS (hazard ratios 1.88 and 1.92). Clustering analysis revealed a subgroup with hormone receptor negative disease that had a favorable PFS and OS.

Conclusion.-Hormone receptors are expressed in the majority of ovarian cancer tumors and may serve as therapeutic targets. Clustering analysis can reveal subgroups with different outcome, which may prove valuable in selecting patients for endocrine therapy. (C) 2015 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)634-639
Number of pages6
JournalGynecologic Oncology
Volume138
Issue number3
DOIs
Publication statusPublished - Sep-2015

Keywords

  • Ovarian cancer
  • Estrogen receptor
  • Progesterone receptor
  • Androgen receptor
  • Biomarker
  • PHASE-II
  • BREAST-CANCER
  • ANDROGEN RECEPTOR
  • EXPRESSION
  • THERAPY
  • CARCINOMA
  • TAMOXIFEN
  • CHEMOTHERAPY
  • FULVESTRANT
  • FLUTAMIDE

Cite this