Host, symbionts, and the microbiome: The missing tripartite interaction

Pina Brinker, Michael C. Fontaine, Leo W Beukeboom, Joana Falcao Salles*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

59 Citations (Scopus)
683 Downloads (Pure)

Abstract

Symbiosis between microbial associates and a host is a ubiquitous feature of life on earth, modulating host phenotypes. In addition to endosymbionts, organisms harbour a collection of host-associated microbes, the microbiome that can impact important host traits. In this opinion article we argue that the mutual influ- ences of the microbiome and endosymbionts, as well as their combined influence on the host, are still understudied. Focusing on the endosymbiont Wolbachia, we present growing evidence indicating that host phenotypic effects are exerted in interaction with the remainder microbiome and the host. We thus advocate that only through an integrated approach that considers multiple interacting partners and environmental influences will we be able to gain a better understanding of host–microbe associations.
Original languageEnglish
Pages (from-to)480-488
Number of pages9
JournalTrends in Microbiology
Volume27
Issue number6
Early online date8-Mar-2019
DOIs
Publication statusPublished - Jun-2019

Keywords

  • GUT MICROBIOTA
  • AEDES-AEGYPTI
  • CYTOPLASMIC INCOMPATIBILITY
  • WOLBACHIA
  • INFECTION
  • COMMUNITY
  • DROSOPHILA
  • ENDOSYMBIONTS
  • EVOLUTION
  • DYNAMICS

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