In this issue of Structure, Tang and colleagues probe how the Flemish mutation in amyloid precursor protein (APP) affects its conformation and cleavage by γ-secretase. They provide molecular insight into how an extracellular inhibitory element and cholesterol interactions affect the generation of Aβ peptides.
- Amyloid beta-Peptides/biosynthesis
- Amyloid beta-Protein Precursor/chemistry
- TRANSMEMBRANE DOMAIN