How amyloid precursor protein protects itself from cleavage

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3 Citations (Scopus)

Abstract

In this issue of Structure, Tang and colleagues probe how the Flemish mutation in amyloid precursor protein (APP) affects its conformation and cleavage by γ-secretase. They provide molecular insight into how an extracellular inhibitory element and cholesterol interactions affect the generation of Aβ peptides.
Original languageEnglish
Pages (from-to)361-362
Number of pages2
JournalStructure
Volume22
Issue number3
DOIs
Publication statusPublished - Mar-2014
Externally publishedYes

Keywords

  • Amyloid beta-Peptides/biosynthesis
  • Amyloid beta-Protein Precursor/chemistry
  • Animals
  • Humans
  • Mutation
  • TRANSMEMBRANE DOMAIN
  • CHOLESTEROL
  • FLEMISH

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