How to distinguish between the vacuum cleaner and flippase mechanisms of the LmrA multi-drug transporter in Lactococcus lactis

JHS Hofmeyr; JM Rohwer; JL Snoep; HV Westerhoff; WN Konings

How to distinguish between the vacuum cleaner and flippase mechanisms of the LmrA multi-drug transporter in Lactococcus lactis

JHS Hofmeyr^*, JM Rohwer, JL Snoep, HV Westerhoff, WN Konings

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Scopus)

Abstract

A numerical model of the LmrA multi-drug transport system of Lactococcus lactis is used to explore the possibility of distinguishing experimentally between two putative transport mechanisms, i.e., the vacuum-cleaner and the flippase mechanisms. This comparative model also serves as an example of numerical simulation with the scripting language Python and its scientific add-on Scipy.

Original language	English
Pages (from-to)	107-112
Number of pages	6
Journal	Molecular Biology Reports
Volume	29
Issue number	1-2
Publication status	Published - 2002

Keywords

flippase
Lactococcus lactis
LmrA
multi-drug resistance
Python/Scipy
vacuum cleaner
RESISTANCE
EXTRUSION

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title = "How to distinguish between the vacuum cleaner and flippase mechanisms of the LmrA multi-drug transporter in Lactococcus lactis",

abstract = "A numerical model of the LmrA multi-drug transport system of Lactococcus lactis is used to explore the possibility of distinguishing experimentally between two putative transport mechanisms, i.e., the vacuum-cleaner and the flippase mechanisms. This comparative model also serves as an example of numerical simulation with the scripting language Python and its scientific add-on Scipy.",

keywords = "flippase, Lactococcus lactis, LmrA, multi-drug resistance, Python/Scipy, vacuum cleaner, RESISTANCE, EXTRUSION",

author = "JHS Hofmeyr and JM Rohwer and JL Snoep and HV Westerhoff and WN Konings",

year = "2002",

language = "English",

volume = "29",

pages = "107--112",

journal = "Molecular Biology Reports",

issn = "0301-4851",

publisher = "Springer",

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T1 - How to distinguish between the vacuum cleaner and flippase mechanisms of the LmrA multi-drug transporter in Lactococcus lactis

AU - Hofmeyr, JHS

AU - Rohwer, JM

AU - Snoep, JL

AU - Westerhoff, HV

AU - Konings, WN

PY - 2002

Y1 - 2002

N2 - A numerical model of the LmrA multi-drug transport system of Lactococcus lactis is used to explore the possibility of distinguishing experimentally between two putative transport mechanisms, i.e., the vacuum-cleaner and the flippase mechanisms. This comparative model also serves as an example of numerical simulation with the scripting language Python and its scientific add-on Scipy.

AB - A numerical model of the LmrA multi-drug transport system of Lactococcus lactis is used to explore the possibility of distinguishing experimentally between two putative transport mechanisms, i.e., the vacuum-cleaner and the flippase mechanisms. This comparative model also serves as an example of numerical simulation with the scripting language Python and its scientific add-on Scipy.

KW - flippase

KW - Lactococcus lactis

KW - LmrA

KW - multi-drug resistance

KW - Python/Scipy

KW - vacuum cleaner

KW - RESISTANCE

KW - EXTRUSION

M3 - Article

SN - 0301-4851

VL - 29

SP - 107

EP - 112

JO - Molecular Biology Reports

JF - Molecular Biology Reports

IS - 1-2

ER -

How to distinguish between the vacuum cleaner and flippase mechanisms of the LmrA multi-drug transporter in Lactococcus lactis

Abstract

Keywords

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