Human genomic data have different statistical properties than the data of randomised controlled trials

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2 Citations (Scopus)

Abstract

Madole & Harden argue that the Mendelian reshuffling of genes and genomes is analogous to randomised controlled trials. We are not convinced by their arguments. First, their recipe for meeting the demands on randomised experiments is inherently inconsistent. Second, disequilibrium across chromosomes conflicts with their assumption of statistical independence. Third, the genome-wide association study (GWAS) method has many pitfalls, including low repeatability.

Original languageEnglish
Article numbere184
JournalBehavioral and Brain Sciences
Volume46
DOIs
Publication statusPublished - 11-Sept-2023

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