Human papillomavirus infection in women with and without cervical cancer in Tbilisi, Georgia

Tamar Alibegashvili; Gary M Clifford; Salvatore Vaccarella; Alexi Baidoshvili; Liana Gogiashvili; Zurab Tsagareli; Ioseb Kureli; Peter J F Snijders; Daniëlle A M Heideman; Folkert J van Kemenade; Chris J L M Meijer; Dimitri Kordzaia; Silvia Franceschi

doi:10.1016/j.canep.2010.12.006

Human papillomavirus infection in women with and without cervical cancer in Tbilisi, Georgia

Tamar Alibegashvili, Gary M Clifford^*, Salvatore Vaccarella, Alexi Baidoshvili, Liana Gogiashvili, Zurab Tsagareli, Ioseb Kureli, Peter J F Snijders, Daniëlle A M Heideman, Folkert J van Kemenade, Chris J L M Meijer, Dimitri Kordzaia, Silvia Franceschi

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BACKGROUND: No accurate estimates of cervical cancer incidence or mortality currently exist in Georgia. Nor are there any data on the population-based prevalence of high-risk (HR) human papillomavirus (HPV) infection, which, in the absence of good-quality screening, is known to correlate with cervical cancer incidence.

METHODS: We obtained cervical cell specimens from 1309 women aged 18-59 years from the general population of Tbilisi, and also from 91 locally diagnosed invasive cervical cancers (ICC). DNA of 44 HPV types was tested for using a GP5+/6+-based PCR assay.

RESULTS: In the general population (of whom 2% reported a previous Pap smear) HPV prevalence was 13.5% (95% CI: 11.6-15.9), being highest in women aged 25-34 years (18.7%) and falling to between 8.6% and 9.5% for all age groups above 34 years. HR HPV prevalence was 8.6% overall, being 6.8% and 38.9% among women with normal and abnormal cytology, respectively. HPV45 (1.6%) was the most common type in women with normal cytology, whereas HPV16 predominated among women with cervical abnormalities (including 7 of 10 histologically confirmed cervical intraepithelial neoplasia 2/3) and among ICC (57.6%). The next most common types in ICC in Georgia were HPV45 and 18 (13.2 and 11.0%, respectively).

CONCLUSIONS: We report a relatively high burden of HPV infection in Tbilisi, Georgia. Improving cervical cancer prevention, through screening and/or HPV vaccination, is an important public health issue in Georgia, where 70% of ICC are theoretically preventable by HPV16/18 vaccines.

Original language	English
Pages (from-to)	465-470
Number of pages	6
Journal	Cancer epidemiology
Volume	35
Issue number	5
DOIs	https://doi.org/10.1016/j.canep.2010.12.006
Publication status	Published - Oct-2011
Externally published	Yes

Keywords

Adolescent
Adult
DNA, Viral/genetics
Female
Follow-Up Studies
Georgia/epidemiology
Humans
Incidence
Mass Screening
Middle Aged
Papanicolaou Test
Papillomaviridae/genetics
Papillomavirus Infections/epidemiology
Prevalence
Prognosis
Risk Factors
Survival Rate
Uterine Cervical Neoplasms/epidemiology
Vaginal Smears
Young Adult
Uterine Cervical Dysplasia/epidemiology

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Human papillomavirus infection in women with and without cervical cancer in Tbilisi, GeorgiaFinal publisher's version, 251 KBLicence: Taverne

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Alibegashvili, T., Clifford, G. M., Vaccarella, S., Baidoshvili, A., Gogiashvili, L., Tsagareli, Z., Kureli, I., Snijders, P. J. F., Heideman, D. A. M., van Kemenade, F. J., Meijer, C. J. L. M., Kordzaia, D., & Franceschi, S. (2011). Human papillomavirus infection in women with and without cervical cancer in Tbilisi, Georgia. Cancer epidemiology, 35(5), 465-470. https://doi.org/10.1016/j.canep.2010.12.006

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title = "Human papillomavirus infection in women with and without cervical cancer in Tbilisi, Georgia",

abstract = "BACKGROUND: No accurate estimates of cervical cancer incidence or mortality currently exist in Georgia. Nor are there any data on the population-based prevalence of high-risk (HR) human papillomavirus (HPV) infection, which, in the absence of good-quality screening, is known to correlate with cervical cancer incidence.METHODS: We obtained cervical cell specimens from 1309 women aged 18-59 years from the general population of Tbilisi, and also from 91 locally diagnosed invasive cervical cancers (ICC). DNA of 44 HPV types was tested for using a GP5+/6+-based PCR assay.RESULTS: In the general population (of whom 2% reported a previous Pap smear) HPV prevalence was 13.5% (95% CI: 11.6-15.9), being highest in women aged 25-34 years (18.7%) and falling to between 8.6% and 9.5% for all age groups above 34 years. HR HPV prevalence was 8.6% overall, being 6.8% and 38.9% among women with normal and abnormal cytology, respectively. HPV45 (1.6%) was the most common type in women with normal cytology, whereas HPV16 predominated among women with cervical abnormalities (including 7 of 10 histologically confirmed cervical intraepithelial neoplasia 2/3) and among ICC (57.6%). The next most common types in ICC in Georgia were HPV45 and 18 (13.2 and 11.0%, respectively).CONCLUSIONS: We report a relatively high burden of HPV infection in Tbilisi, Georgia. Improving cervical cancer prevention, through screening and/or HPV vaccination, is an important public health issue in Georgia, where 70% of ICC are theoretically preventable by HPV16/18 vaccines.",

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author = "Tamar Alibegashvili and Clifford, {Gary M} and Salvatore Vaccarella and Alexi Baidoshvili and Liana Gogiashvili and Zurab Tsagareli and Ioseb Kureli and Snijders, {Peter J F} and Heideman, {Dani{\"e}lle A M} and {van Kemenade}, {Folkert J} and Meijer, {Chris J L M} and Dimitri Kordzaia and Silvia Franceschi",

year = "2011",

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doi = "10.1016/j.canep.2010.12.006",

language = "English",

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Alibegashvili, T, Clifford, GM, Vaccarella, S, Baidoshvili, A, Gogiashvili, L, Tsagareli, Z, Kureli, I, Snijders, PJF, Heideman, DAM, van Kemenade, FJ, Meijer, CJLM, Kordzaia, D & Franceschi, S 2011, 'Human papillomavirus infection in women with and without cervical cancer in Tbilisi, Georgia', Cancer epidemiology, vol. 35, no. 5, pp. 465-470. https://doi.org/10.1016/j.canep.2010.12.006

TY - JOUR

T1 - Human papillomavirus infection in women with and without cervical cancer in Tbilisi, Georgia

AU - Alibegashvili, Tamar

AU - Clifford, Gary M

AU - Vaccarella, Salvatore

AU - Baidoshvili, Alexi

AU - Gogiashvili, Liana

AU - Tsagareli, Zurab

AU - Kureli, Ioseb

AU - Snijders, Peter J F

AU - Heideman, Daniëlle A M

AU - van Kemenade, Folkert J

AU - Meijer, Chris J L M

AU - Kordzaia, Dimitri

AU - Franceschi, Silvia

PY - 2011/10

Y1 - 2011/10

N2 - BACKGROUND: No accurate estimates of cervical cancer incidence or mortality currently exist in Georgia. Nor are there any data on the population-based prevalence of high-risk (HR) human papillomavirus (HPV) infection, which, in the absence of good-quality screening, is known to correlate with cervical cancer incidence.METHODS: We obtained cervical cell specimens from 1309 women aged 18-59 years from the general population of Tbilisi, and also from 91 locally diagnosed invasive cervical cancers (ICC). DNA of 44 HPV types was tested for using a GP5+/6+-based PCR assay.RESULTS: In the general population (of whom 2% reported a previous Pap smear) HPV prevalence was 13.5% (95% CI: 11.6-15.9), being highest in women aged 25-34 years (18.7%) and falling to between 8.6% and 9.5% for all age groups above 34 years. HR HPV prevalence was 8.6% overall, being 6.8% and 38.9% among women with normal and abnormal cytology, respectively. HPV45 (1.6%) was the most common type in women with normal cytology, whereas HPV16 predominated among women with cervical abnormalities (including 7 of 10 histologically confirmed cervical intraepithelial neoplasia 2/3) and among ICC (57.6%). The next most common types in ICC in Georgia were HPV45 and 18 (13.2 and 11.0%, respectively).CONCLUSIONS: We report a relatively high burden of HPV infection in Tbilisi, Georgia. Improving cervical cancer prevention, through screening and/or HPV vaccination, is an important public health issue in Georgia, where 70% of ICC are theoretically preventable by HPV16/18 vaccines.

AB - BACKGROUND: No accurate estimates of cervical cancer incidence or mortality currently exist in Georgia. Nor are there any data on the population-based prevalence of high-risk (HR) human papillomavirus (HPV) infection, which, in the absence of good-quality screening, is known to correlate with cervical cancer incidence.METHODS: We obtained cervical cell specimens from 1309 women aged 18-59 years from the general population of Tbilisi, and also from 91 locally diagnosed invasive cervical cancers (ICC). DNA of 44 HPV types was tested for using a GP5+/6+-based PCR assay.RESULTS: In the general population (of whom 2% reported a previous Pap smear) HPV prevalence was 13.5% (95% CI: 11.6-15.9), being highest in women aged 25-34 years (18.7%) and falling to between 8.6% and 9.5% for all age groups above 34 years. HR HPV prevalence was 8.6% overall, being 6.8% and 38.9% among women with normal and abnormal cytology, respectively. HPV45 (1.6%) was the most common type in women with normal cytology, whereas HPV16 predominated among women with cervical abnormalities (including 7 of 10 histologically confirmed cervical intraepithelial neoplasia 2/3) and among ICC (57.6%). The next most common types in ICC in Georgia were HPV45 and 18 (13.2 and 11.0%, respectively).CONCLUSIONS: We report a relatively high burden of HPV infection in Tbilisi, Georgia. Improving cervical cancer prevention, through screening and/or HPV vaccination, is an important public health issue in Georgia, where 70% of ICC are theoretically preventable by HPV16/18 vaccines.

KW - Adolescent

KW - Adult

KW - DNA, Viral/genetics

KW - Female

KW - Follow-Up Studies

KW - Georgia/epidemiology

KW - Humans

KW - Incidence

KW - Mass Screening

KW - Middle Aged

KW - Papanicolaou Test

KW - Papillomaviridae/genetics

KW - Papillomavirus Infections/epidemiology

KW - Prevalence

KW - Prognosis

KW - Risk Factors

KW - Survival Rate

KW - Uterine Cervical Neoplasms/epidemiology

KW - Vaginal Smears

KW - Young Adult

KW - Uterine Cervical Dysplasia/epidemiology

U2 - 10.1016/j.canep.2010.12.006

DO - 10.1016/j.canep.2010.12.006

M3 - Article

C2 - 21292583

SN - 1877-7821

VL - 35

SP - 465

EP - 470

JO - Cancer epidemiology

JF - Cancer epidemiology

IS - 5

ER -

Human papillomavirus infection in women with and without cervical cancer in Tbilisi, Georgia

Abstract

Keywords

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