Human papillomavirus infection in women with and without cervical cancer in Tehran, Iran

Nahid Khodakarami; Gary M Clifford; Parvin Yavari; Farah Farzaneh; Saghar Salehpour; Natalie Broutet; Heli Bathija; Daniëlle A M Heideman; Folkert J van Kemenade; Chris J L M Meijer; Seyed Jalil Hosseini; Silvia Franceschi

doi:10.1002/ijc.26488

Human papillomavirus infection in women with and without cervical cancer in Tehran, Iran

Nahid Khodakarami
, Gary M Clifford^*
, Parvin Yavari
, Farah Farzaneh
, Saghar Salehpour
, Natalie Broutet
, Heli Bathija
, Daniëlle A M Heideman
, Folkert J van Kemenade
, Chris J L M Meijer
, Seyed Jalil Hosseini
, Silvia Franceschi

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

No data exist on the population prevalence of, or risk factors for, human papillomavirus (HPV) infection in Iran or the Middle East. Cervical specimens were obtained from 825 married women aged 18-59 years from the general population of Tehran, Iran and from 45 locally diagnosed invasive cervical cancers (ICC) according to the standardized protocol of the International Agency for Research on Cancer HPV Prevalence Surveys. HPV was detected and genotyped using a GP5+/6+ PCR-based assay. HPV prevalence in the general population was 7.8% (95% confidence interval: 6.0-9.8) (5.1% of high-risk types), with no significant variation by age. HPV positivity was significantly higher among divorced women, women in polygamous marriages and those reporting husband's absence from home for >7 nights/month. HPV16/18 accounted for 30 and 82.2% of HPV-positive women in the general population and ICC, respectively. Cervical cancer prevention policies should take into account the relatively low HPV prevalence in this population.

Original language	English
Pages (from-to)	E156-E161
Journal	International Journal of Cancer
Volume	131
Issue number	2
DOIs	https://doi.org/10.1002/ijc.26488
Publication status	Published - 15-Jul-2012
Externally published	Yes

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Female
Human papillomavirus 16/isolation & purification
Human papillomavirus 18/isolation & purification
Humans
Iran/epidemiology
Middle Aged
Papillomavirus Infections/epidemiology
Uterine Cervical Neoplasms/epidemiology
Young Adult
Uterine Cervical Dysplasia/epidemiology

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10.1002/ijc.26488

Human papillomavirus infection in women with and without cervical cancerFinal publisher's version, 167 KBLicence: Taverne

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Khodakarami, N., Clifford, G. M., Yavari, P., Farzaneh, F., Salehpour, S., Broutet, N., Bathija, H., Heideman, D. A. M., van Kemenade, F. J., Meijer, C. J. L. M., Hosseini, S. J., & Franceschi, S. (2012). Human papillomavirus infection in women with and without cervical cancer in Tehran, Iran. International Journal of Cancer, 131(2), E156-E161. https://doi.org/10.1002/ijc.26488

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title = "Human papillomavirus infection in women with and without cervical cancer in Tehran, Iran",

abstract = "No data exist on the population prevalence of, or risk factors for, human papillomavirus (HPV) infection in Iran or the Middle East. Cervical specimens were obtained from 825 married women aged 18-59 years from the general population of Tehran, Iran and from 45 locally diagnosed invasive cervical cancers (ICC) according to the standardized protocol of the International Agency for Research on Cancer HPV Prevalence Surveys. HPV was detected and genotyped using a GP5+/6+ PCR-based assay. HPV prevalence in the general population was 7.8\% (95\% confidence interval: 6.0-9.8) (5.1\% of high-risk types), with no significant variation by age. HPV positivity was significantly higher among divorced women, women in polygamous marriages and those reporting husband's absence from home for >7 nights/month. HPV16/18 accounted for 30 and 82.2\% of HPV-positive women in the general population and ICC, respectively. Cervical cancer prevention policies should take into account the relatively low HPV prevalence in this population.",

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year = "2012",

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doi = "10.1002/ijc.26488",

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AU - Broutet, Natalie

AU - Bathija, Heli

AU - Heideman, Daniëlle A M

AU - van Kemenade, Folkert J

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AU - Hosseini, Seyed Jalil

AU - Franceschi, Silvia

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AB - No data exist on the population prevalence of, or risk factors for, human papillomavirus (HPV) infection in Iran or the Middle East. Cervical specimens were obtained from 825 married women aged 18-59 years from the general population of Tehran, Iran and from 45 locally diagnosed invasive cervical cancers (ICC) according to the standardized protocol of the International Agency for Research on Cancer HPV Prevalence Surveys. HPV was detected and genotyped using a GP5+/6+ PCR-based assay. HPV prevalence in the general population was 7.8% (95% confidence interval: 6.0-9.8) (5.1% of high-risk types), with no significant variation by age. HPV positivity was significantly higher among divorced women, women in polygamous marriages and those reporting husband's absence from home for >7 nights/month. HPV16/18 accounted for 30 and 82.2% of HPV-positive women in the general population and ICC, respectively. Cervical cancer prevention policies should take into account the relatively low HPV prevalence in this population.

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Human papillomavirus infection in women with and without cervical cancer in Tehran, Iran

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Keywords

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