Hydration of nitriles using a metal-ligand cooperative ruthenium pincer catalyst

Beibei Guo, Johannes G. de Vries, Edwin Otten*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)
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Abstract

Nitrile hydration provides access to amides that are important structural elements in organic chemistry. Here we report catalytic nitrile hydration using ruthenium catalysts based on a pincer scaffold with a dearomatized pyridine backbone. These complexes catalyze the nucleophilic addition of H2O to a wide variety of aliphatic and (hetero)aromatic nitriles in (BuOH)-Bu-t as solvent. Reactions occur under mild conditions (room temperature) in the absence of additives. A mechanism for nitrile hydration is proposed that is initiated by metal-ligand cooperative binding of the nitrile.

Original languageEnglish
Pages (from-to)10647-10652
Number of pages6
JournalChemical Science
Volume10
Issue number45
DOIs
Publication statusPublished - 7-Dec-2019

Keywords

  • BOND FORMATION
  • TEMPLATE CATALYSIS
  • MICHAEL ADDITIONS
  • WATER ACTIVATION
  • COMPLEXES
  • HYDROLYSIS
  • AMINO
  • ACID
  • CO2
  • RU

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