Hydrogenosomes: convergent adaptations of mitochondria to anaerobic environments

JHP Hackstein*, A Akhmanova, F Voncken, A van Hoek, T van Alen, B Boxma, SY Moon-van der Staay, G van der Staay, J Leunissen, M Huynen, J Rosenberg, M Veenhuis, Johannes H.P. Hackstein, Seung Yeo Moon-van der Staay

*Corresponding author for this work

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Abstract

Hydrogenosomes are membrane-bound organelles that compartmentalise the Final steps of energy metabo I is in in a number of anaerobic eukaryotes. They produce hydrogen and ATP. Here we will review the data, which are relevant for the questions: how did the hydrogenosomes originate, and what was their ancestor? Notably, there is strong evidence that hydrogenosomes evolved several times as adaptations to anaerobic environments. Most likely, hydrogenosomes and mitochondria share a common ancestor, but an unequivocal proof for this hypothesis is difficult because hydrogenosomes lack an organelle genome - with one remarkable exception (Nyctoherus ovalis). In particular, the diversity of extant hydrogenosomes hampers a straightforward analysis of their origins. Nevertheless, it is conceivable to postulate that the common ancestor of mitochondria and hydrogenosomes was a facultative anaerobic organelle that participated in the early radiation of unicellular eukaryotes. Consequently, it is reasonable to assume that both, hydrogenosomes and mitochondria are evolutionary adaptations to anaerobic or aerobic environments, respectively.

Original languageEnglish
Pages (from-to)290-302
Number of pages13
JournalZoology-Analysis of Complex Systems
Volume104
Issue number3-4
DOIs
Publication statusPublished - 2001
Event94th Annual Meeting of the German-Zoological-Society - , Germany
Duration: 4-Jun-20018-Jun-2001

Keywords

  • hydrogenosomes
  • mitochondria
  • evolution
  • eukaryotes
  • anaerobes
  • FUNGUS NEOCALLIMASTIX-FRONTALIS
  • PARASITE ENTAMOEBA-HISTOLYTICA
  • NYCTOTHERUS-OVALIS
  • TRICHOMONAS-VAGINALIS
  • METHANOGENIC BACTERIA
  • GASTROINTESTINAL-TRACT
  • MICROBIAL ECOLOGY
  • ENERGY GENERATION
  • TARGETING SIGNAL
  • DOUBLE MEMBRANE

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