Hypertensive response to exercise in adult patients with repaired aortic coarctation

Timion A. Meijs*, Steven A. Muller, Savine C. S. Minderhoud, Robbert J. de Winter, Barbara J. M. Mulder, Joost P. van Melle, Elke S. Hoendermis, Arie P. J. van Dijk, Nicolaas P. A. Zuithoff, Gregor J. Krings, Pieter A. Doevendans, Wilko Spiering, Maarten Witsenburg, Jolien W. Roos-Hesselink, Annemien E. van den Bosch, Berto J. Bouma, Michiel Voskuil

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Objective The clinical and prognostic implications of a hypertensive response to exercise after repair of coarctation of the aorta (CoA) remain controversial. We aimed to determine the prevalence of a hypertensive response to exercise, identify factors associated with peak exercise systolic blood pressure (SBP) and explore the association of peak exercise SBP with resting blood pressure and cardiovascular events during follow-up. Methods From the Dutch national CONgenital CORvitia (CONCOR) registry, adults with repaired CoA who underwent exercise stress testing were included. A hypertensive response to exercise was defined as a peak exercise SBP >= 210 mm Hg in men and >= 190 mm Hg in women. Cardiovascular events consisted of coronary artery disease, stroke, aortic complications and cardiovascular death. Results Of the original cohort of 920 adults with repaired CoA, 675 patients (median age 24 years (range 16-72 years)) underwent exercise stress testing. Of these, 299 patients (44%) had a hypertensive response to exercise. Mean follow-up duration was 10.1 years. Male sex, absence of a bicuspid aortic valve and elevated resting SBP were independently associated with increased peak exercise SBP. Peak exercise SBP was positively predictive of office SBP (beta=0.11, p

Original languageEnglish
Number of pages8
Publication statusE-pub ahead of print - 5-Jan-2022


  • heart defects
  • congenital
  • aortic coarctation
  • hypertension

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