Hyponatriëmie bij gebruik van selectieve serotonineheropnameremmers: meldingen in 1992-2002

Translated title of the contribution: Hyponatraemia during the use of selective serotonin re-uptake inhibitors (SSRIs): reports from 1992-2002

H H Wijnen, F M E van Schendel, M G M Olde Rikkert, C S van der Hooft, E P van Puijenbroek

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

OBJECTIVE: To describe the reports of serotonin re-uptake inhibitor (SSRI)-induced hyponatraemia that were sent to The Netherlands Pharmacovigilance Centre Lareb and the Inspectorate for Health Care.

DESIGN: Descriptive study.

METHOD: Reports of SSRI-induced hyponatraemia received by Lareb and the Inspectorate for Health Care during the period 1 January 1992 to 1 July 2002 were described on the basis of symptoms, co-medication and comorbidity. RESULTS; A total of 42 cases were reported, 38 (90%) of which concerned women and 21 (50%) of which concerned the concomitant use of SSRIs and diuretics. The mean age was 74 years (range: 30-91). The mean serum sodium concentration was 115 mmol/l (range: 97-132). The most important symptoms were reduced consciousness, confusion, falls, nausea and vomiting. 3 patients (7%) died in the period of the reported adverse drug reaction and 27 patients (64%) were hospitalised, of which 4 (10%) to the intensive care unit.

CONCLUSION: These reports of suspected SSRI-induced hyponatraemia were attended with significant morbidity and substantial mortality. The considerable morbidity and substantial mortality in combination with the increasing use of SSRIs necessitates a clarification of the actual incidence and severity of SSRI-induced hyponatraemia.

Translated title of the contributionHyponatraemia during the use of selective serotonin re-uptake inhibitors (SSRIs): reports from 1992-2002
Original languageDutch
Pages (from-to)1921-1924
Number of pages4
JournalNederlands Tijdschrift voor de Geneeskunde
Volume148
Issue number39
Publication statusPublished - 25-Sept-2004
Externally publishedYes

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Cause of Death
  • Diuretics
  • Female
  • Hospitalization
  • Humans
  • Hyponatremia
  • Incidence
  • Male
  • Middle Aged
  • Netherlands
  • Serotonin Uptake Inhibitors
  • Sodium

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