Hypopharyngeal carcinoma after radiation for tuberculosis: Radiation-induced carcinoma

Lisa van der Putten; Remco de Bree; Dirk J. Kuik; Derek H. F. Rietveld; Johannes A. Langendijk; C. Rene Leemans

doi:10.1016/j.oraloncology.2010.06.013

Hypopharyngeal carcinoma after radiation for tuberculosis: Radiation-induced carcinoma

Lisa van der Putten, Remco de Bree^*, Dirk J. Kuik, Derek H. F. Rietveld, Johannes A. Langendijk, C. Rene Leemans

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

Radiation may cause radiation-induced cancers after a long latency period. In a group of 111 patients surgically treated for hypopharyngeal carcinoma, patients previously treated with radiotherapy for tuberculosis in the neck were compared to patients without previous radiotherapy. Seven patients (7.4%) underwent radiotherapy (median age 15 years) and developed a hypopharyngeal carcinoma (median age 70 years, median latency period 54.4 year). Considering this long latency period and the localisation in the previous radiation field these tumours can be classified as potentially radiation-induced carcinomas. Patients with potentially radiation-induced carcinomas were significantly older when the hypopharyngeal carcinoma was diagnosed (p = 0.048), were more frequently females (p = 0.05) and had a worse 5-year regional control rate (p = 0.048). When radiotherapy is considered in young patients the risk of induction of tumours has to be kept in mind. (C) 2010 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	672-677
Number of pages	6
Journal	Oral Oncology
Volume	46
Issue number	9
DOIs	https://doi.org/10.1016/j.oraloncology.2010.06.013
Publication status	Published - Sept-2010

Keywords

Head and neck cancer
Radiation-induced cancer
Hypopharynx
INDUCED CANCERS
INDUCED TUMORS
NECK REGION
HEAD
RISK
SARCOMA

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@article{6394a95ed9144b9e8c1b72757ff075bf,

title = "Hypopharyngeal carcinoma after radiation for tuberculosis: Radiation-induced carcinoma",

abstract = "Radiation may cause radiation-induced cancers after a long latency period. In a group of 111 patients surgically treated for hypopharyngeal carcinoma, patients previously treated with radiotherapy for tuberculosis in the neck were compared to patients without previous radiotherapy. Seven patients (7.4%) underwent radiotherapy (median age 15 years) and developed a hypopharyngeal carcinoma (median age 70 years, median latency period 54.4 year). Considering this long latency period and the localisation in the previous radiation field these tumours can be classified as potentially radiation-induced carcinomas. Patients with potentially radiation-induced carcinomas were significantly older when the hypopharyngeal carcinoma was diagnosed (p = 0.048), were more frequently females (p = 0.05) and had a worse 5-year regional control rate (p = 0.048). When radiotherapy is considered in young patients the risk of induction of tumours has to be kept in mind. (C) 2010 Elsevier Ltd. All rights reserved.",

keywords = "Head and neck cancer, Radiation-induced cancer, Hypopharynx, INDUCED CANCERS, INDUCED TUMORS, NECK REGION, HEAD, RISK, SARCOMA",

author = "{van der Putten}, Lisa and {de Bree}, Remco and Kuik, {Dirk J.} and Rietveld, {Derek H. F.} and Langendijk, {Johannes A.} and Leemans, {C. Rene}",

year = "2010",

month = sep,

doi = "10.1016/j.oraloncology.2010.06.013",

language = "English",

volume = "46",

pages = "672--677",

journal = "Oral Oncology",

issn = "1368-8375",

publisher = "ELSEVIER SCIENCE BV",

number = "9",

}

TY - JOUR

T1 - Hypopharyngeal carcinoma after radiation for tuberculosis

T2 - Radiation-induced carcinoma

AU - van der Putten, Lisa

AU - de Bree, Remco

AU - Kuik, Dirk J.

AU - Rietveld, Derek H. F.

AU - Langendijk, Johannes A.

AU - Leemans, C. Rene

PY - 2010/9

Y1 - 2010/9

N2 - Radiation may cause radiation-induced cancers after a long latency period. In a group of 111 patients surgically treated for hypopharyngeal carcinoma, patients previously treated with radiotherapy for tuberculosis in the neck were compared to patients without previous radiotherapy. Seven patients (7.4%) underwent radiotherapy (median age 15 years) and developed a hypopharyngeal carcinoma (median age 70 years, median latency period 54.4 year). Considering this long latency period and the localisation in the previous radiation field these tumours can be classified as potentially radiation-induced carcinomas. Patients with potentially radiation-induced carcinomas were significantly older when the hypopharyngeal carcinoma was diagnosed (p = 0.048), were more frequently females (p = 0.05) and had a worse 5-year regional control rate (p = 0.048). When radiotherapy is considered in young patients the risk of induction of tumours has to be kept in mind. (C) 2010 Elsevier Ltd. All rights reserved.

AB - Radiation may cause radiation-induced cancers after a long latency period. In a group of 111 patients surgically treated for hypopharyngeal carcinoma, patients previously treated with radiotherapy for tuberculosis in the neck were compared to patients without previous radiotherapy. Seven patients (7.4%) underwent radiotherapy (median age 15 years) and developed a hypopharyngeal carcinoma (median age 70 years, median latency period 54.4 year). Considering this long latency period and the localisation in the previous radiation field these tumours can be classified as potentially radiation-induced carcinomas. Patients with potentially radiation-induced carcinomas were significantly older when the hypopharyngeal carcinoma was diagnosed (p = 0.048), were more frequently females (p = 0.05) and had a worse 5-year regional control rate (p = 0.048). When radiotherapy is considered in young patients the risk of induction of tumours has to be kept in mind. (C) 2010 Elsevier Ltd. All rights reserved.

KW - Head and neck cancer

KW - Radiation-induced cancer

KW - Hypopharynx

KW - INDUCED CANCERS

KW - INDUCED TUMORS

KW - NECK REGION

KW - HEAD

KW - RISK

KW - SARCOMA

U2 - 10.1016/j.oraloncology.2010.06.013

DO - 10.1016/j.oraloncology.2010.06.013

M3 - Article

SN - 1368-8375

VL - 46

SP - 672

EP - 677

JO - Oral Oncology

JF - Oral Oncology

IS - 9

ER -

Hypopharyngeal carcinoma after radiation for tuberculosis: Radiation-induced carcinoma

Abstract

Keywords

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