Hypothermic machine perfusion in liver transplantation

S. Karangwa, G. Panayotova, P. Dutkowski, R. J. Porte, J. Guarrera, A. Schlegel*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)
13 Downloads (Pure)

Abstract

Dynamic preservation strategies are a promising option to improve graft quality before transplantation, and to extend preservation time for either logistic or treatment reasons. In contrast to normothermic oxygenated perfusion, which intends to mimic physiological conditions in the human body, with subsequent clinical application for up to 24 hrs, hypothermic perfusion is mainly used for a relatively short period with protection of mitochondria and subsequent reduction of oxidative injury upon implantation. The results from two randomized controlled trials, where recruitment has finished are expected this year. Both ex situ perfusion techniques are increasingly applied in clinical transplantation including recent reports on viability assessment, which could open the door for an increased liver utilization in the future.

Original languageEnglish
Pages (from-to)44-51
Number of pages8
JournalInternational Journal of Surgery
Volume82
DOIs
Publication statusPublished - Oct-2020

Keywords

  • Hypothermic liver perfusion
  • Mitochondria
  • Viability assessment
  • Biliary complications
  • ANASTOMOTIC BILIARY STRICTURES
  • OXYGENATED PERFUSION
  • CONTROLLED DONATION
  • COLD-STORAGE
  • DONOR LIVERS
  • COMPLICATIONS
  • INJURY
  • HOPE
  • PRESERVATION
  • GRAFTS

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