Hypoxia imaging using Positron Emission Tomography in non-small cell lung cancer: Implications for radiotherapy

Vikram Rao Bollineni*, Erwin M. Wiegman, Jan Pruim, Harry J. M. Groen, Johannes A. Langendijk

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

31 Citations (Scopus)

Abstract

Tumour hypoxia is an important contributor to radioresistance. Thus, increasing the radiation dose to hypoxic areas may result in improved locoregional tumour control. However, this strategy requires accurate detection of the hypoxic sub-volume using PET imaging. Secondly, hypoxia imaging may also provide prognostic information and may be of help to monitor treatment response. Therefore, a systematic review of the scientific literature was carried out on the use of Positron Emission Tomography (PET) to image Tumour hypoxia in non-small cell lung cancer (NSCLC). More specifically, the purpose of this review was (1) to summarize the different hypoxia tracers used, (2) to investigate whether Tumour hypoxia can be detected in NSCLC and finally (3) whether the presence of hypoxia can be used to predict outcome. (C) 2012 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)1027-1032
Number of pages6
JournalCANCER TREATMENT REVIEWS
Volume38
Issue number8
DOIs
Publication statusPublished - Dec-2012

Keywords

  • Hypoxia
  • PET
  • Dose escalation
  • NSCLC
  • HIGH LACTATE LEVELS
  • TUMOR HYPOXIA
  • F-18 FLUOROMISONIDAZOLE
  • NECK-CANCER
  • OXYGENATION STATUS
  • HIF-ALPHA
  • IN-VIVO
  • RADIATION
  • HEAD

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