Identical chromosome translocations involving the region of the c-myb oncogene in four metastases of a mediastinal teratocarcinoma

J. Wolter Oosterhuis; Bauke de Jong; Ineke van Dalen; Ingrid van der Meer; Margreet Visser; Loe de Leij; Geert Mesander; John G. Collard; Heimen Schraffordt Koops; Dirk Th. Sleijfer

doi:10.1016/0165-4608(85)90136-0

Identical chromosome translocations involving the region of the c-myb oncogene in four metastases of a mediastinal teratocarcinoma

J. Wolter Oosterhuis^*, Bauke de Jong, Ineke van Dalen, Ingrid van der Meer, Margreet Visser, Loe de Leij, Geert Mesander, John G. Collard, Heimen Schraffordt Koops, Dirk Th. Sleijfer

^*Corresponding author for this work

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Abstract

A 39-year-old white male presented with a disseminated mediastinal teratocarcinoma. Karyotyping was performed on two mature residual metastatic lesions in the lungs immediately following chemotherapy, on a recurring lung lesion after 5 months, and on a metastasis in the right thigh 5 months after salvage chemotherapy. All four lesions were pseudoeuploid and showed identical chromosomal abnormalities: a translocation with the two chromosomes #6 and one chromosome #11 involved, resulting in 46, XY, t (6;6;11) (q21;q23;q13). The breakpoint in chromosome #6 is in the region to which the oncogene c-myb has been localized, and the breakpoint in chromosome #11 is at a known fragile and possibly oncogenic site, suggesting that the translocations in this case may have played a crucial role in the development of the malignancy.

Original language	English
Pages (from-to)	99-107
Number of pages	9
Journal	Cancer Genetics and Cytogenetics
Volume	15
Issue number	1-2
DOIs	https://doi.org/10.1016/0165-4608(85)90136-0
Publication status	Published - 1985

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Identical chromosome translocations involving the region of the c-myb oncogene in four metastases of a mediastinal teratocarcinoma
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Oosterhuis, J. W., de Jong, B., van Dalen, I., van der Meer, I., Visser, M., de Leij, L., Mesander, G., Collard, J. G., Schraffordt Koops, H., & Sleijfer, D. T. (1985). Identical chromosome translocations involving the region of the c-myb oncogene in four metastases of a mediastinal teratocarcinoma. Cancer Genetics and Cytogenetics, 15(1-2), 99-107. https://doi.org/10.1016/0165-4608(85)90136-0

@article{d92e866a64b44dae9c7db9cff31c8829,

title = "Identical chromosome translocations involving the region of the c-myb oncogene in four metastases of a mediastinal teratocarcinoma",

abstract = "A 39-year-old white male presented with a disseminated mediastinal teratocarcinoma. Karyotyping was performed on two mature residual metastatic lesions in the lungs immediately following chemotherapy, on a recurring lung lesion after 5 months, and on a metastasis in the right thigh 5 months after salvage chemotherapy. All four lesions were pseudoeuploid and showed identical chromosomal abnormalities: a translocation with the two chromosomes #6 and one chromosome #11 involved, resulting in 46, XY, t (6;6;11) (q21;q23;q13). The breakpoint in chromosome #6 is in the region to which the oncogene c-myb has been localized, and the breakpoint in chromosome #11 is at a known fragile and possibly oncogenic site, suggesting that the translocations in this case may have played a crucial role in the development of the malignancy.",

author = "Oosterhuis, {J. Wolter} and {de Jong}, Bauke and {van Dalen}, Ineke and {van der Meer}, Ingrid and Margreet Visser and {de Leij}, Loe and Geert Mesander and Collard, {John G.} and {Schraffordt Koops}, Heimen and Sleijfer, {Dirk Th.}",

year = "1985",

doi = "10.1016/0165-4608(85)90136-0",

language = "English",

volume = "15",

pages = "99--107",

journal = "Cancer Genetics and Cytogenetics",

issn = "0165-4608",

publisher = "ELSEVIER SCIENCE INC",

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Oosterhuis, JW, de Jong, B, van Dalen, I, van der Meer, I, Visser, M, de Leij, L, Mesander, G, Collard, JG, Schraffordt Koops, H & Sleijfer, DT 1985, 'Identical chromosome translocations involving the region of the c-myb oncogene in four metastases of a mediastinal teratocarcinoma', Cancer Genetics and Cytogenetics, vol. 15, no. 1-2, pp. 99-107. https://doi.org/10.1016/0165-4608(85)90136-0

TY - JOUR

T1 - Identical chromosome translocations involving the region of the c-myb oncogene in four metastases of a mediastinal teratocarcinoma

AU - Oosterhuis, J. Wolter

AU - de Jong, Bauke

AU - van Dalen, Ineke

AU - van der Meer, Ingrid

AU - Visser, Margreet

AU - de Leij, Loe

AU - Mesander, Geert

AU - Collard, John G.

AU - Schraffordt Koops, Heimen

AU - Sleijfer, Dirk Th.

PY - 1985

Y1 - 1985

N2 - A 39-year-old white male presented with a disseminated mediastinal teratocarcinoma. Karyotyping was performed on two mature residual metastatic lesions in the lungs immediately following chemotherapy, on a recurring lung lesion after 5 months, and on a metastasis in the right thigh 5 months after salvage chemotherapy. All four lesions were pseudoeuploid and showed identical chromosomal abnormalities: a translocation with the two chromosomes #6 and one chromosome #11 involved, resulting in 46, XY, t (6;6;11) (q21;q23;q13). The breakpoint in chromosome #6 is in the region to which the oncogene c-myb has been localized, and the breakpoint in chromosome #11 is at a known fragile and possibly oncogenic site, suggesting that the translocations in this case may have played a crucial role in the development of the malignancy.

AB - A 39-year-old white male presented with a disseminated mediastinal teratocarcinoma. Karyotyping was performed on two mature residual metastatic lesions in the lungs immediately following chemotherapy, on a recurring lung lesion after 5 months, and on a metastasis in the right thigh 5 months after salvage chemotherapy. All four lesions were pseudoeuploid and showed identical chromosomal abnormalities: a translocation with the two chromosomes #6 and one chromosome #11 involved, resulting in 46, XY, t (6;6;11) (q21;q23;q13). The breakpoint in chromosome #6 is in the region to which the oncogene c-myb has been localized, and the breakpoint in chromosome #11 is at a known fragile and possibly oncogenic site, suggesting that the translocations in this case may have played a crucial role in the development of the malignancy.

U2 - 10.1016/0165-4608(85)90136-0

DO - 10.1016/0165-4608(85)90136-0

M3 - Article

SN - 0165-4608

VL - 15

SP - 99

EP - 107

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 1-2

ER -

Identical chromosome translocations involving the region of the c-myb oncogene in four metastases of a mediastinal teratocarcinoma

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