Identification of a novel genomic island associated with vanD-type vancomycin-resistance in six Dutch vancomycin-resistant Enterococcus faecium

Janetta Top; Jan C Sinnige; Ellen C Brouwer; Guido Werner; Jukka Corander; Juliëtte A Severin; Rogier Jansen; E Bathoorn; Marc J M Bonten; John W A Rossen; Rob J L Willems

doi:10.1128/AAC.01793-17

Identification of a novel genomic island associated with vanD-type vancomycin-resistance in six Dutch vancomycin-resistant Enterococcus faecium

Janetta Top, Jan C Sinnige, Ellen C Brouwer, Guido Werner, Jukka Corander, Juliëtte A Severin, Rogier Jansen, E Bathoorn, Marc J M Bonten, John W A Rossen, Rob J L Willems

Microbes in Health and Disease (MHD)

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Genomic comparison of the first six Dutch vanD-type vancomycin-resistant Enterococcus faecium (VRE) with four vanD-gene clusters from other enterococcal species and anaerobic gut commensals revealed that the vanD-gene cluster was located on a genomic island of variable size. Phylogenetic inferences revealed that the Dutch-VRE were genetically not closely related and genetic variation of the vanD-genomic island was not species specific, which suggest that this island is transferred horizontally between enterococci and anaerobic gut commensals.

Original language	English
Article number	e01793-17
Journal	Antimicrobial Agents and Chemotherapy
Volume	62
Issue number	3
Early online date	8-Jan-2018
DOIs	https://doi.org/10.1128/AAC.01793-17
Publication status	Published - Mar-2018

Keywords

Journal Article
CANADA
FLORA
MOLECULAR CHARACTERIZATION
CONJUGATIVE ELEMENTS
GENE-CLUSTER
FAECALIS

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10.1128/AAC.01793-17

Identification of a Novel Genomic Island AssociatedFinal publisher's version, 1.54 MB

Cite this

Top, J., Sinnige, J. C., Brouwer, E. C., Werner, G., Corander, J., Severin, J. A., Jansen, R., Bathoorn, E., Bonten, M. J. M., Rossen, J. W. A., & Willems, R. J. L. (2018). Identification of a novel genomic island associated with vanD-type vancomycin-resistance in six Dutch vancomycin-resistant Enterococcus faecium. Antimicrobial Agents and Chemotherapy, 62(3), [e01793-17]. https://doi.org/10.1128/AAC.01793-17

Top, Janetta ; Sinnige, Jan C ; Brouwer, Ellen C ; Werner, Guido ; Corander, Jukka ; Severin, Juliëtte A ; Jansen, Rogier ; Bathoorn, E ; Bonten, Marc J M ; Rossen, John W A ; Willems, Rob J L. / Identification of a novel genomic island associated with vanD-type vancomycin-resistance in six Dutch vancomycin-resistant Enterococcus faecium. In: Antimicrobial Agents and Chemotherapy. 2018 ; Vol. 62, No. 3.

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title = "Identification of a novel genomic island associated with vanD-type vancomycin-resistance in six Dutch vancomycin-resistant Enterococcus faecium",

abstract = "Genomic comparison of the first six Dutch vanD-type vancomycin-resistant Enterococcus faecium (VRE) with four vanD-gene clusters from other enterococcal species and anaerobic gut commensals revealed that the vanD-gene cluster was located on a genomic island of variable size. Phylogenetic inferences revealed that the Dutch-VRE were genetically not closely related and genetic variation of the vanD-genomic island was not species specific, which suggest that this island is transferred horizontally between enterococci and anaerobic gut commensals.",

keywords = "Journal Article, CANADA, FLORA, MOLECULAR CHARACTERIZATION, CONJUGATIVE ELEMENTS, GENE-CLUSTER, FAECALIS",

author = "Janetta Top and Sinnige, {Jan C} and Brouwer, {Ellen C} and Guido Werner and Jukka Corander and Severin, {Juli{\"e}tte A} and Rogier Jansen and E Bathoorn and Bonten, {Marc J M} and Rossen, {John W A} and Willems, {Rob J L}",

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doi = "10.1128/AAC.01793-17",

language = "English",

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journal = "Antimicrobial Agents and Chemotherapy",

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Top, J, Sinnige, JC, Brouwer, EC, Werner, G, Corander, J, Severin, JA, Jansen, R, Bathoorn, E, Bonten, MJM, Rossen, JWA & Willems, RJL 2018, 'Identification of a novel genomic island associated with vanD-type vancomycin-resistance in six Dutch vancomycin-resistant Enterococcus faecium', Antimicrobial Agents and Chemotherapy, vol. 62, no. 3, e01793-17. https://doi.org/10.1128/AAC.01793-17

Identification of a novel genomic island associated with vanD-type vancomycin-resistance in six Dutch vancomycin-resistant Enterococcus faecium. / Top, Janetta; Sinnige, Jan C; Brouwer, Ellen C; Werner, Guido; Corander, Jukka; Severin, Juliëtte A; Jansen, Rogier; Bathoorn, E; Bonten, Marc J M; Rossen, John W A; Willems, Rob J L.

In: Antimicrobial Agents and Chemotherapy, Vol. 62, No. 3, e01793-17, 03.2018.

Research output: Contribution to journal › Article › Academic › peer-review

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