Identification of a novel genomic island associated with vanD-type vancomycin-resistance in six Dutch vancomycin-resistant Enterococcus faecium

Janetta Top, Jan C Sinnige, Ellen C Brouwer, Guido Werner, Jukka Corander, Juliëtte A Severin, Rogier Jansen, E Bathoorn, Marc J M Bonten, John W A Rossen, Rob J L Willems

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Abstract

Genomic comparison of the first six Dutch vanD-type vancomycin-resistant Enterococcus faecium (VRE) with four vanD-gene clusters from other enterococcal species and anaerobic gut commensals revealed that the vanD-gene cluster was located on a genomic island of variable size. Phylogenetic inferences revealed that the Dutch-VRE were genetically not closely related and genetic variation of the vanD-genomic island was not species specific, which suggest that this island is transferred horizontally between enterococci and anaerobic gut commensals.

Original languageEnglish
Article numbere01793-17
JournalAntimicrobial Agents and Chemotherapy
Volume62
Issue number3
Early online date8-Jan-2018
DOIs
Publication statusPublished - Mar-2018

Keywords

  • Journal Article
  • CANADA
  • FLORA
  • MOLECULAR CHARACTERIZATION
  • CONJUGATIVE ELEMENTS
  • GENE-CLUSTER
  • FAECALIS

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