@article{ed040068a2404d6bab735f72d12a002e,
title = "Identification of context-dependent expression quantitative trait loci in whole blood",
abstract = "Genetic risk factors often localize to noncoding regions of the genome with unknown effects on disease etiology1,2. Expression quantitative trait loci (eQTLs) help to explain the regulatory mechanisms underlying these genetic associations(3-6). Knowledge of the context that determines the nature and strength of eQTLs may help identify cell types relevant to pathophysiology and the regulatory networks underlying disease(7-17). Here we generated peripheral blood RNA-seq data from 2,116 unrelated individuals and systematically identified context-dependent eQTLs using a hypothesis-free strategy that does not require previous knowledge of the identity of the modifiers. Of the 23,060 significant cis-regulated genes (false discovery rate (FDR)",
keywords = "GENE-EXPRESSION, DISEASE ASSOCIATIONS, HUMAN NEUTROPHILS, CELL, GENOME, VARIANTS, OBESITY, ENRICHMENT, INFECTION, ALLELES",
author = "Daria Pital-Zhernakova and Patrick Deelen and Martijn Vermaat and {van Iterson}, Maarten and {van Galen}, Michiel and Wibowo Arindrarto and {van 't Hof}, Peter and Hailiang Mei and {van Dijk}, Freerk and Harm-Jan Westra and Bonder, {Marc Jan} and {van Rooij}, Jeroen and Marijn Verkerk and Jhamai, {P. Mila} and Matthijs Moed and Kielbasa, {Szymon M.} and Jan Bot and Irene Nooren and Rene Pool and {van Dongen}, Jenny and Hottenga, {Jouke J.} and Stehouwer, {Coen D. A.} and {van der Kallen}, {Carla J. H.} and Schalkwijk, {Casper G.} and Alexandra Zhernakova and Yang Li and Tigchelaar, {Ettje F.} and {de Klein}, Niek and Marian Beekman and Joris Deelen and {van Heemst}, Diana and {van den Berg}, {Leonard H.} and Albert Hofman and Uitterlinden, {Andre G.} and {van Greevenbroek}, {Marleen M. J.} and Veldink, {Jan H.} and Boomsma, {Dorret I.} and {van Duijn}, {Cornelia M.} and Cisca Wijmenga and Slagboom, {P. Eline} and Swertz, {Morris A.} and Aaron Isaacs and {van Meurs}, {Joyce B. J.} and Rick Jansen and Heijmans, {Bastiaan T.} and {'t Hoen}, {Peter A. C.} and Lude Franke",
year = "2017",
month = jan,
doi = "10.1038/ng.3737",
language = "English",
volume = "49",
pages = "139--145",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "1",
}