Identification of Hsp70 modulators through modeling of the substrate binding domain

Conor M. Haney; Corinne Schneider; Barbara Beck; Jeffrey L. Brodsky; Alexander Doemling

doi:10.1016/j.bmcl.2009.04.062

Identification of Hsp70 modulators through modeling of the substrate binding domain

Conor M. Haney, Corinne Schneider, Barbara Beck, Jeffrey L. Brodsky, Alexander Doemling^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Scopus)

Abstract

The design, synthesis and preliminary activity of small molecular weight modulators of the heat shock protein 70 (Hsp70) are described. The compounds provide a starting point for the synthesis of novel tools to decipher Hsp70 biology. (C) 2009 Published by Elsevier Ltd.

Original language	English
Pages (from-to)	3828-3831
Number of pages	4
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	19
Issue number	14
DOIs	https://doi.org/10.1016/j.bmcl.2009.04.062
Publication status	Published - 15-Jul-2009
Externally published	Yes

Keywords

HSP-70
Multi component reaction
Ugi reaction
Isocyanide
Protein protein interaction
Modulator
Peptide recognition site
MOLECULAR CHAPERONE FUNCTION
PEPTIDE BINDING
ATPASE ACTIVITY
DNAK
PROTEINS
AFFINITY

Access to Document

10.1016/j.bmcl.2009.04.062

Cite this

@article{15312e5c06754da5b760f906129d3798,

title = "Identification of Hsp70 modulators through modeling of the substrate binding domain",

abstract = "The design, synthesis and preliminary activity of small molecular weight modulators of the heat shock protein 70 (Hsp70) are described. The compounds provide a starting point for the synthesis of novel tools to decipher Hsp70 biology. (C) 2009 Published by Elsevier Ltd.",

keywords = "HSP-70, Multi component reaction, Ugi reaction, Isocyanide, Protein protein interaction, Modulator, Peptide recognition site, MOLECULAR CHAPERONE FUNCTION, PEPTIDE BINDING, ATPASE ACTIVITY, DNAK, PROTEINS, AFFINITY",

author = "Haney, {Conor M.} and Corinne Schneider and Barbara Beck and Brodsky, {Jeffrey L.} and Alexander Doemling",

year = "2009",

month = jul,

day = "15",

doi = "10.1016/j.bmcl.2009.04.062",

language = "English",

volume = "19",

pages = "3828--3831",

journal = "Bioorganic & Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "American Chemical Society",

number = "14",

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TY - JOUR

T1 - Identification of Hsp70 modulators through modeling of the substrate binding domain

AU - Haney, Conor M.

AU - Schneider, Corinne

AU - Beck, Barbara

AU - Brodsky, Jeffrey L.

AU - Doemling, Alexander

PY - 2009/7/15

Y1 - 2009/7/15

N2 - The design, synthesis and preliminary activity of small molecular weight modulators of the heat shock protein 70 (Hsp70) are described. The compounds provide a starting point for the synthesis of novel tools to decipher Hsp70 biology. (C) 2009 Published by Elsevier Ltd.

AB - The design, synthesis and preliminary activity of small molecular weight modulators of the heat shock protein 70 (Hsp70) are described. The compounds provide a starting point for the synthesis of novel tools to decipher Hsp70 biology. (C) 2009 Published by Elsevier Ltd.

KW - HSP-70

KW - Multi component reaction

KW - Ugi reaction

KW - Isocyanide

KW - Protein protein interaction

KW - Modulator

KW - Peptide recognition site

KW - MOLECULAR CHAPERONE FUNCTION

KW - PEPTIDE BINDING

KW - ATPASE ACTIVITY

KW - DNAK

KW - PROTEINS

KW - AFFINITY

U2 - 10.1016/j.bmcl.2009.04.062

DO - 10.1016/j.bmcl.2009.04.062

M3 - Article

VL - 19

SP - 3828

EP - 3831

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

SN - 0960-894X

IS - 14

ER -