Identification of Novel Translational Urinary Biomarkers for Acetaminophen-Induced Acute Liver Injury Using Proteomic Profiling in Mice

Rachel P. L. van Swelm; Coby M. M. Laarakkers; Ellen C. van der Kuur; Eva Morava-Kozicz; Ron A. Wevers; Kevin D. Augustijn; Daan J. Touw; Maro H. Sandel; Rosalinde Masereeuw; Frans G. M. Russel

doi:10.1371/journal.pone.0049524

Identification of Novel Translational Urinary Biomarkers for Acetaminophen-Induced Acute Liver Injury Using Proteomic Profiling in Mice

Rachel P. L. van Swelm, Coby M. M. Laarakkers, Ellen C. van der Kuur, Eva Morava-Kozicz, Ron A. Wevers, Kevin D. Augustijn, Daan J. Touw, Maro H. Sandel, Rosalinde Masereeuw, Frans G. M. Russel

Research output: Contribution to journal › Article › Academic › peer-review

14 Citations (Scopus)

190 Downloads (Pure)

Abstract

Drug-induced liver injury (DILI) is the leading cause of acute liver failure. Currently, no adequate predictive biomarkers for DILI are available. This study describes a translational approach using proteomic profiling for the identification of urinary proteins related to acute liver injury induced by acetaminophen (APAP). Mice were given a single intraperitoneal dose of APAP (0-350 mg/kg bw) followed by 24 h urine collection. Doses of ≥275 mg/kg bw APAP resulted in hepatic centrilobular necrosis and significantly elevated plasma alanine aminotransferase (ALT) values (p

Original language	English
Article number	e49524
Number of pages	11
Journal	PLoS ONE
Volume	7
Issue number	11
DOIs	https://doi.org/10.1371/journal.pone.0049524
Publication status	Published - 14-Nov-2012

Keywords

acetylsalicylic acid
alanine aminotransferase
alendronic acid
alprazolam
amoxicillin plus clavulanic acid
biological marker
caffeine
calmodulin
carbonate dehydratase III
copper zinc superoxide dismutase
cotrimoxazole
diazepam
dipyridamole
furosemide
ibuprofen
lercanidipine
metacetamol
metoprolol
omeprazole
pantoprazole
paracetamol
adult
aged
alanine aminotransferase blood level
animal experiment
animal model
article
body weight
controlled study
female
follow up
human
human tissue
liver necrosis
male
mouse
nephrotoxicity
nonhuman
protein analysis
protein urine level
proteomics
toxic hepatitis
urinalysis

Access to Document

10.1371/journal.pone.0049524Licence: CC BY

Identification of Novel Translational Urinary Biomarkers for Acetaminophen-Induced Acute Liver Injury Using Proteomic Profiling in MiceFinal publisher's version, 1.18 MBLicence: CC BY

Handle.net

Persistent link

Cite this

van Swelm, R. P. L., Laarakkers, C. M. M., van der Kuur, E. C., Morava-Kozicz, E., Wevers, R. A., Augustijn, K. D., Touw, D. J., Sandel, M. H., Masereeuw, R., & Russel, F. G. M. (2012). Identification of Novel Translational Urinary Biomarkers for Acetaminophen-Induced Acute Liver Injury Using Proteomic Profiling in Mice. PLoS ONE, 7(11), Article e49524. https://doi.org/10.1371/journal.pone.0049524

@article{6a882589f6924f57922d106799a26757,

title = "Identification of Novel Translational Urinary Biomarkers for Acetaminophen-Induced Acute Liver Injury Using Proteomic Profiling in Mice",

abstract = "Drug-induced liver injury (DILI) is the leading cause of acute liver failure. Currently, no adequate predictive biomarkers for DILI are available. This study describes a translational approach using proteomic profiling for the identification of urinary proteins related to acute liver injury induced by acetaminophen (APAP). Mice were given a single intraperitoneal dose of APAP (0-350 mg/kg bw) followed by 24 h urine collection. Doses of ≥275 mg/kg bw APAP resulted in hepatic centrilobular necrosis and significantly elevated plasma alanine aminotransferase (ALT) values (p",

keywords = "acetylsalicylic acid, alanine aminotransferase, alendronic acid, alprazolam, amoxicillin plus clavulanic acid, biological marker, caffeine, calmodulin, carbonate dehydratase III, copper zinc superoxide dismutase, cotrimoxazole, diazepam, dipyridamole, furosemide, ibuprofen, lercanidipine, metacetamol, metoprolol, omeprazole, pantoprazole, paracetamol, adult, aged, alanine aminotransferase blood level, animal experiment, animal model, article, body weight, controlled study, female, follow up, human, human tissue, liver necrosis, male, mouse, nephrotoxicity, nonhuman, protein analysis, protein urine level, proteomics, toxic hepatitis, urinalysis",

author = "{van Swelm}, {Rachel P. L.} and Laarakkers, {Coby M. M.} and {van der Kuur}, {Ellen C.} and Eva Morava-Kozicz and Wevers, {Ron A.} and Augustijn, {Kevin D.} and Touw, {Daan J.} and Sandel, {Maro H.} and Rosalinde Masereeuw and Russel, {Frans G. M.}",

year = "2012",

month = nov,

day = "14",

doi = "10.1371/journal.pone.0049524",

language = "English",

volume = "7",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "PUBLIC LIBRARY SCIENCE",

number = "11",

}

TY - JOUR

T1 - Identification of Novel Translational Urinary Biomarkers for Acetaminophen-Induced Acute Liver Injury Using Proteomic Profiling in Mice

AU - van Swelm, Rachel P. L.

AU - Laarakkers, Coby M. M.

AU - van der Kuur, Ellen C.

AU - Morava-Kozicz, Eva

AU - Wevers, Ron A.

AU - Augustijn, Kevin D.

AU - Touw, Daan J.

AU - Sandel, Maro H.

AU - Masereeuw, Rosalinde

AU - Russel, Frans G. M.

PY - 2012/11/14

Y1 - 2012/11/14

N2 - Drug-induced liver injury (DILI) is the leading cause of acute liver failure. Currently, no adequate predictive biomarkers for DILI are available. This study describes a translational approach using proteomic profiling for the identification of urinary proteins related to acute liver injury induced by acetaminophen (APAP). Mice were given a single intraperitoneal dose of APAP (0-350 mg/kg bw) followed by 24 h urine collection. Doses of ≥275 mg/kg bw APAP resulted in hepatic centrilobular necrosis and significantly elevated plasma alanine aminotransferase (ALT) values (p

AB - Drug-induced liver injury (DILI) is the leading cause of acute liver failure. Currently, no adequate predictive biomarkers for DILI are available. This study describes a translational approach using proteomic profiling for the identification of urinary proteins related to acute liver injury induced by acetaminophen (APAP). Mice were given a single intraperitoneal dose of APAP (0-350 mg/kg bw) followed by 24 h urine collection. Doses of ≥275 mg/kg bw APAP resulted in hepatic centrilobular necrosis and significantly elevated plasma alanine aminotransferase (ALT) values (p

KW - acetylsalicylic acid

KW - alanine aminotransferase

KW - alendronic acid

KW - alprazolam

KW - amoxicillin plus clavulanic acid

KW - biological marker

KW - caffeine

KW - calmodulin

KW - carbonate dehydratase III

KW - copper zinc superoxide dismutase

KW - cotrimoxazole

KW - diazepam

KW - dipyridamole

KW - furosemide

KW - ibuprofen

KW - lercanidipine

KW - metacetamol

KW - metoprolol

KW - omeprazole

KW - pantoprazole

KW - paracetamol

KW - adult

KW - aged

KW - alanine aminotransferase blood level

KW - animal experiment

KW - animal model

KW - article

KW - body weight

KW - controlled study

KW - female

KW - follow up

KW - human

KW - human tissue

KW - liver necrosis

KW - male

KW - mouse

KW - nephrotoxicity

KW - nonhuman

KW - protein analysis

KW - protein urine level

KW - proteomics

KW - toxic hepatitis

KW - urinalysis

U2 - 10.1371/journal.pone.0049524

DO - 10.1371/journal.pone.0049524

M3 - Article

C2 - 23166697

SN - 1932-6203

VL - 7

JO - PLoS ONE

JF - PLoS ONE

IS - 11

M1 - e49524

ER -

Identification of Novel Translational Urinary Biomarkers for Acetaminophen-Induced Acute Liver Injury Using Proteomic Profiling in Mice

Abstract

Keywords

Access to Document

Handle.net

Fingerprint

Cite this