Identification of three new DRB1 alleles, DRB1*0107,*0425 and*13012 and confirmation of DRB4*01033

C.E.M. Voorter; B.G. Hepkema; S.P.M. Lems; E.M van den Berg-Loonen

doi:10.1034/j.1399-0039.2003.00034.x

Identification of three new DRB1 alleles, DRB10107,0425 and13012 and confirmation of DRB401033

C.E.M. Voorter
, B.G. Hepkema
, S.P.M. Lems
, E.M van den Berg-Loonen

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

The characterization of three novel DRB1 alleles is described, DRB1*0107, DRB1*0425 and DRB1*13012 as well as confirmation of DRB4*01033. Two alleles, DRB1*0107 and *0425, showed amino acid differences with previously identified HLA molecules. In DRB1*0107, the glutamine at position 10 was substituted by a glutamic acid. DRB1*0425 showed one amino acid difference with DRB1*0418 (I to F) at position 67, and five amino acid differences with DRB1*04011 at positions 67 (L to F), 70 (Q to D), 71 (K to R), 74 (A to L) and 86 (G to V). The alleles DRB1*13012 and DRB4*01033 had protein sequences identical to DRB1*13011 and DRB4*01031/01032, respectively. Nucleotide differences were present at position 306 for DRB1*13012 and at position 321 for DRB4*01033

Original language	Dutch
Pages (from-to)	398 - 402
Number of pages	5
Journal	TISSUE ANTIGENS
Volume	61
Issue number	5
DOIs	https://doi.org/10.1034/j.1399-0039.2003.00034.x
Publication status	Published - 2003

Keywords

DRB1*0107
DRB1*0425
DRB1*13012
DRB4*01033
HLA-DRB
new allele
sequence-based typing
POLYMERASE CHAIN-REACTION
T-CELL-RECEPTOR
HLA-DR4 DRA-ASTERISK-0101
CRYSTAL-STRUCTURE
HLA-DR
PEPTIDE
POLYMORPHISM
DRB1-ASTERISK-0401
RESTRICTION
LOCUS

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Cite this

@article{cc28062e599c4baa989446a6d80ad7d2,

title = "Identification of three new DRB1 alleles, DRB1*0107,*0425 and*13012 and confirmation of DRB4*01033",

abstract = "The characterization of three novel DRB1 alleles is described, DRB1*0107, DRB1*0425 and DRB1*13012 as well as confirmation of DRB4*01033. Two alleles, DRB1*0107 and *0425, showed amino acid differences with previously identified HLA molecules. In DRB1*0107, the glutamine at position 10 was substituted by a glutamic acid. DRB1*0425 showed one amino acid difference with DRB1*0418 (I to F) at position 67, and five amino acid differences with DRB1*04011 at positions 67 (L to F), 70 (Q to D), 71 (K to R), 74 (A to L) and 86 (G to V). The alleles DRB1*13012 and DRB4*01033 had protein sequences identical to DRB1*13011 and DRB4*01031/01032, respectively. Nucleotide differences were present at position 306 for DRB1*13012 and at position 321 for DRB4*01033",

keywords = "DRB1*0107, DRB1*0425, DRB1*13012, DRB4*01033, HLA-DRB, new allele, sequence-based typing, POLYMERASE CHAIN-REACTION, T-CELL-RECEPTOR, HLA-DR4 DRA-ASTERISK-0101, CRYSTAL-STRUCTURE, HLA-DR, PEPTIDE, POLYMORPHISM, DRB1-ASTERISK-0401, RESTRICTION, LOCUS",

author = "C.E.M. Voorter and B.G. Hepkema and S.P.M. Lems and \{van den Berg-Loonen\}, E.M",

note = "Article",

year = "2003",

doi = "10.1034/j.1399-0039.2003.00034.x",

language = "Dutch",

volume = "61",

pages = "398 -- 402",

journal = "TISSUE ANTIGENS",

issn = "0001-2815",

publisher = "BLACKWELL PUBLISHING",

number = "5",

}

TY - JOUR

T1 - Identification of three new DRB1 alleles, DRB1*0107,*0425 and*13012 and confirmation of DRB4*01033

AU - Voorter, C.E.M.

AU - Hepkema, B.G.

AU - Lems, S.P.M.

AU - van den Berg-Loonen, E.M

N1 - Article

PY - 2003

Y1 - 2003

N2 - The characterization of three novel DRB1 alleles is described, DRB1*0107, DRB1*0425 and DRB1*13012 as well as confirmation of DRB4*01033. Two alleles, DRB1*0107 and *0425, showed amino acid differences with previously identified HLA molecules. In DRB1*0107, the glutamine at position 10 was substituted by a glutamic acid. DRB1*0425 showed one amino acid difference with DRB1*0418 (I to F) at position 67, and five amino acid differences with DRB1*04011 at positions 67 (L to F), 70 (Q to D), 71 (K to R), 74 (A to L) and 86 (G to V). The alleles DRB1*13012 and DRB4*01033 had protein sequences identical to DRB1*13011 and DRB4*01031/01032, respectively. Nucleotide differences were present at position 306 for DRB1*13012 and at position 321 for DRB4*01033

AB - The characterization of three novel DRB1 alleles is described, DRB1*0107, DRB1*0425 and DRB1*13012 as well as confirmation of DRB4*01033. Two alleles, DRB1*0107 and *0425, showed amino acid differences with previously identified HLA molecules. In DRB1*0107, the glutamine at position 10 was substituted by a glutamic acid. DRB1*0425 showed one amino acid difference with DRB1*0418 (I to F) at position 67, and five amino acid differences with DRB1*04011 at positions 67 (L to F), 70 (Q to D), 71 (K to R), 74 (A to L) and 86 (G to V). The alleles DRB1*13012 and DRB4*01033 had protein sequences identical to DRB1*13011 and DRB4*01031/01032, respectively. Nucleotide differences were present at position 306 for DRB1*13012 and at position 321 for DRB4*01033

KW - DRB10107

KW - DRB10425

KW - DRB113012

KW - DRB401033

KW - HLA-DRB

KW - new allele

KW - sequence-based typing

KW - POLYMERASE CHAIN-REACTION

KW - T-CELL-RECEPTOR

KW - HLA-DR4 DRA-ASTERISK-0101

KW - CRYSTAL-STRUCTURE

KW - HLA-DR

KW - PEPTIDE

KW - POLYMORPHISM

KW - DRB1-ASTERISK-0401

KW - RESTRICTION

KW - LOCUS

U2 - 10.1034/j.1399-0039.2003.00034.x

DO - 10.1034/j.1399-0039.2003.00034.x

M3 - Article

SN - 0001-2815

VL - 61

SP - 398

EP - 402

JO - TISSUE ANTIGENS

JF - TISSUE ANTIGENS

IS - 5

ER -