IL-1RN gene polymorphism is associated with peri-implantitis

Marja L. Laine, Asa Leonhardt, Ann-Marie Roos-Jansaker, A. Salvador Pena, Arie Jan van Winkelhoff, Edwin G. Winkel, Stefan Renvert*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

97 Citations (Scopus)

Abstract

Objectives: Interleukin (IL)-1 alpha, IL-1 beta and their natural specific inhibitor IL-1 receptor antagonist (IL-1ra) play a key role in the regulation of the inflammatory response in periodontal tissues. Polymorphisms in the IL-1 gene cluster have been associated with severe adult periodontitis. We aimed to investigate the IL-1 gene cluster polymorphisms in patients with peri-implantitis.

Material and methods: The study included 120 North Caucasian individuals. A total of 71 patients (mean age 68 years, 76% smokers) demonstrating peri-implantitis at one or more implants as evidenced by bleeding and/or pus on probing and bone loss amounting to > 3 threads on Branemark implants and 49 controls (mean age 66 years, 45% smokers) with clinical healthy mucosa and no bone loss around the implants were recruited for the study. The titanium implants, ad modum Branemark, had been in function for at least 2 years. Mouthwash samples were collected and used for genotyping of the bi-allelic polymorphisms IL-1A(-889), IL-1B(+3953), IL-1B(-511) and a variable number of tandem repeat IL-1RN gene polymorphisms using PCR technique.

Results: Significant differences were found in the carriage rate of allele 2 in the IL-1RN gene between peri-implantitis patients and controls (56.5% vs. 33.3%, respectively; odds ratios (OR) 2.6; 95% confidence interval (CI) 1.2-5.6; P=0.015). Logistic regression analysis taking smoking, gender and age into account confirmed the association between the IL-1RN allele 2 carriers and peri-implantitis (OR 3; 95% CI 1.2-7.6; P=0.02).

Conclusions: Our results provide evidence that IL-1RN gene polymorphism is associated with peri-implantitis and may represent a risk factor for this disease.

Original languageEnglish
Pages (from-to)380-385
Number of pages6
JournalCLINICAL ORAL IMPLANTS RESEARCH
Volume17
Issue number4
DOIs
Publication statusPublished - Aug-2006

Keywords

  • gene polymorphism
  • interleukin-1
  • peri-implantitis
  • smoking
  • INTERLEUKIN-1 RECEPTOR ANTAGONIST
  • TUMOR-NECROSIS-FACTOR
  • PERIODONTAL-DISEASE
  • OSSEOINTEGRATED IMPLANTS
  • ALLELIC POLYMORPHISM
  • TISSUE DESTRUCTION
  • ULCERATIVE-COLITIS
  • SEVERITY FACTOR
  • ORAL IMPLANTS
  • BONE LOSS

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