IL-33 induced gene expression in activated Th2 effector cells is dependent on IL-1RL1 haplotype and asthma status

Akshaya Keerthi Saikumar Jayalatha; Marlies E Ketelaar; Laura Hesse; Yusef E Badi; Nazanin Zounemat-Kermani; Sharon Brouwer; Nicole F Dijk; Maarten van den Berge; Victor Guryev; Ian Sayers; Judith E Vonk; Ian M Adcock; Gerard H Koppelman; Martijn C Nawijn

doi:10.1183/13993003.00005-2024

IL-33 induced gene expression in activated Th2 effector cells is dependent on IL-1RL1 haplotype and asthma status

Akshaya Keerthi Saikumar Jayalatha, Marlies E Ketelaar, Laura Hesse, Yusef E Badi, Nazanin Zounemat-Kermani, Sharon Brouwer, Nicole F Dijk, Maarten van den Berge, Victor Guryev, Ian Sayers, Judith E Vonk, Ian M Adcock, Gerard H Koppelman, Martijn C Nawijn^*

^*Corresponding author for this work

Research output: Contribution to journal › Letter › Academic › peer-review

2 Citations (Scopus)

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Abstract

IL-33 response in Th2 cells is specific to asthma and represents a high risk haplotype, highlighting its role in airway wall cells. Yet, its detection is challenging in bulk asthma transcriptomes due to the scarcity of effector Th2 cells. https://bit.ly/3WhuMbo

Original language	English
Article number	2400005
Number of pages	5
Journal	The European respiratory journal
Volume	63
Issue number	6
DOIs	https://doi.org/10.1183/13993003.00005-2024
Publication status	Published - Jun-2024

Keywords

Asthma/genetics
Humans
Interleukin-33/genetics
Interleukin-1 Receptor-Like 1 Protein/genetics
Haplotypes
Th2 Cells/immunology
Interleukins/genetics
Polymorphism, Single Nucleotide
Gene Expression Regulation

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IL-33 induced gene expression in activated Th2 effector cells is dependent on IL-1RL1 haplotype and asthma statusFinal publisher's version, 857 KBLicence: CC BY

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Saikumar Jayalatha, A. K., Ketelaar, M. E., Hesse, L., Badi, Y. E., Zounemat-Kermani, N., Brouwer, S., Dijk, N. F., van den Berge, M., Guryev, V., Sayers, I., Vonk, J. E., Adcock, I. M., Koppelman, G. H., & Nawijn, M. C. (2024). IL-33 induced gene expression in activated Th2 effector cells is dependent on IL-1RL1 haplotype and asthma status. The European respiratory journal, 63(6), Article 2400005. https://doi.org/10.1183/13993003.00005-2024

@article{7dd2d175e49d41bc927177c8868b8df9,

title = "IL-33 induced gene expression in activated Th2 effector cells is dependent on IL-1RL1 haplotype and asthma status",

abstract = " IL-33 response in Th2 cells is specific to asthma and represents a high risk haplotype, highlighting its role in airway wall cells. Yet, its detection is challenging in bulk asthma transcriptomes due to the scarcity of effector Th2 cells. https://bit.ly/3WhuMbo ",

keywords = "Asthma/genetics, Humans, Interleukin-33/genetics, Interleukin-1 Receptor-Like 1 Protein/genetics, Haplotypes, Th2 Cells/immunology, Interleukins/genetics, Polymorphism, Single Nucleotide, Gene Expression Regulation",

author = "{Saikumar Jayalatha}, {Akshaya Keerthi} and Ketelaar, {Marlies E} and Laura Hesse and Badi, {Yusef E} and Nazanin Zounemat-Kermani and Sharon Brouwer and Dijk, {Nicole F} and {van den Berge}, Maarten and Victor Guryev and Ian Sayers and Vonk, {Judith E} and Adcock, {Ian M} and Koppelman, {Gerard H} and Nawijn, {Martijn C}",

year = "2024",

month = jun,

doi = "10.1183/13993003.00005-2024",

language = "English",

volume = "63",

journal = "The European respiratory journal",

issn = "0903-1936",

publisher = "EUROPEAN RESPIRATORY SOC JOURNALS LTD",

number = "6",

}

Saikumar Jayalatha, AK, Ketelaar, ME, Hesse, L, Badi, YE, Zounemat-Kermani, N, Brouwer, S, Dijk, NF, van den Berge, M , Guryev, V, Sayers, I, Vonk, JE, Adcock, IM, Koppelman, GH & Nawijn, MC 2024, 'IL-33 induced gene expression in activated Th2 effector cells is dependent on IL-1RL1 haplotype and asthma status', The European respiratory journal, vol. 63, no. 6, 2400005. https://doi.org/10.1183/13993003.00005-2024

TY - JOUR

T1 - IL-33 induced gene expression in activated Th2 effector cells is dependent on IL-1RL1 haplotype and asthma status

AU - Saikumar Jayalatha, Akshaya Keerthi

AU - Ketelaar, Marlies E

AU - Hesse, Laura

AU - Badi, Yusef E

AU - Zounemat-Kermani, Nazanin

AU - Brouwer, Sharon

AU - Dijk, Nicole F

AU - van den Berge, Maarten

AU - Guryev, Victor

AU - Sayers, Ian

AU - Vonk, Judith E

AU - Adcock, Ian M

AU - Koppelman, Gerard H

AU - Nawijn, Martijn C

PY - 2024/6

Y1 - 2024/6

N2 - IL-33 response in Th2 cells is specific to asthma and represents a high risk haplotype, highlighting its role in airway wall cells. Yet, its detection is challenging in bulk asthma transcriptomes due to the scarcity of effector Th2 cells. https://bit.ly/3WhuMbo

AB - IL-33 response in Th2 cells is specific to asthma and represents a high risk haplotype, highlighting its role in airway wall cells. Yet, its detection is challenging in bulk asthma transcriptomes due to the scarcity of effector Th2 cells. https://bit.ly/3WhuMbo

KW - Asthma/genetics

KW - Humans

KW - Interleukin-33/genetics

KW - Interleukin-1 Receptor-Like 1 Protein/genetics

KW - Haplotypes

KW - Th2 Cells/immunology

KW - Interleukins/genetics

KW - Polymorphism, Single Nucleotide

KW - Gene Expression Regulation

U2 - 10.1183/13993003.00005-2024

DO - 10.1183/13993003.00005-2024

M3 - Letter

C2 - 38843913

SN - 0903-1936

VL - 63

JO - The European respiratory journal

JF - The European respiratory journal

IS - 6

M1 - 2400005

ER -

IL-33 induced gene expression in activated Th2 effector cells is dependent on IL-1RL1 haplotype and asthma status

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