Abstract

Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease characterized by dysfunction and lymphocytic infiltration of the salivary and lacrimal glands. Besides the characteristic sicca complaints, pSS patients can present a spectrum of signs and symptoms, which challenges the diagnostic process. Various imaging techniques can be used to assist in the diagnostic work-up and follow-up of pSS patients. Developments in imaging techniques provide new opportunities and perspectives. In this descriptive review, we discuss imaging techniques that are used in pSS with a focus on the salivary glands. The emphasis is on the contribution of these techniques to the diagnosis of pSS, their potential in assessing disease activity and disease progression in pSS, and their contribution to diagnosing and staging of pSS-associated lymphomas. Imaging findings of the salivary glands will be linked to histopathological changes in the salivary glands of pSS patients.

Original languageEnglish
Article number2492
Number of pages21
JournalJournal of Clinical Medicine
Volume9
Issue number8
DOIs
Publication statusPublished - 3-Aug-2020

Keywords

  • primary Sjogren's syndrome
  • imaging
  • salivary gland
  • sialography
  • salivary gland ultrasonography
  • magnetic resonance imaging
  • sialendoscopy
  • salivary gland scintigraphy
  • positron emission tomography
  • SALIVARY-GLAND ULTRASONOGRAPHY
  • MAGNETIC-RESONANCE SIALOGRAPHY
  • POSITRON-EMISSION-TOMOGRAPHY
  • NON-HODGKINS-LYMPHOMA
  • CLASSIFICATION CRITERIA
  • PAROTID-GLAND
  • PROGNOSTIC VALUE
  • LACRIMAL GLAND
  • FOCUS SCORE
  • MALIGNANT-LYMPHOMA

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