TY - JOUR
T1 - Imaging of cardiac and renal perfusion in a rat model with N-13-NH3 micro-PET
AU - Juarez-Orozco, Luis E.
AU - Szymanski, Mariusz K.
AU - Hillege, Hans L.
AU - Kruizinga, Silvana
AU - Noordzij, Walter
AU - Koole, Michel
AU - Tio, Rene A.
AU - Alexanderson, Erick
AU - Dierckx, Rudi A. J. O.
AU - Slart, Riemer H. J. A.
PY - 2015/1
Y1 - 2015/1
N2 - Cardiac dysfunction leads to decreased organ perfusion. We aimed to measure cardiac and renal perfusion simultaneously with the use of N-13-NH3-microPET in different rat models. Ten male Wistar rats underwent sham surgery (n = 5) or permanent coronary artery ligation to induce myocardial infarction (MI, n = 5). Eleven weeks later N-13-NH3-microPET scan was performed to study the cardiac and renal perfusion. Cardiac perfusion was significantly reduced in MI group, directly correlated with ejection fraction and inversely correlated with MI size (r = 0.89; p <0.001 and r = -0.86; p <0.001 respectively). Renal perfusion showed a notional 17 % non-significant reduction in MI group when compared to sham (3.44 +/- A 0.40 vs. 4.12 +/- A 0.48 ml/g/min). There was a trend towards greater reduction of perfusion in cortical than medullar region. Cortex perfusion was negatively correlated with histological changes. N-13-NH3-microPET may be a potential tool for evaluation of cardiac and renal functional and perfusion changes in presence of cardiac dysfunction in rat models.
AB - Cardiac dysfunction leads to decreased organ perfusion. We aimed to measure cardiac and renal perfusion simultaneously with the use of N-13-NH3-microPET in different rat models. Ten male Wistar rats underwent sham surgery (n = 5) or permanent coronary artery ligation to induce myocardial infarction (MI, n = 5). Eleven weeks later N-13-NH3-microPET scan was performed to study the cardiac and renal perfusion. Cardiac perfusion was significantly reduced in MI group, directly correlated with ejection fraction and inversely correlated with MI size (r = 0.89; p <0.001 and r = -0.86; p <0.001 respectively). Renal perfusion showed a notional 17 % non-significant reduction in MI group when compared to sham (3.44 +/- A 0.40 vs. 4.12 +/- A 0.48 ml/g/min). There was a trend towards greater reduction of perfusion in cortical than medullar region. Cortex perfusion was negatively correlated with histological changes. N-13-NH3-microPET may be a potential tool for evaluation of cardiac and renal functional and perfusion changes in presence of cardiac dysfunction in rat models.
KW - Cardiorenal
KW - PET
KW - Perfusion
KW - N-13-ammonia
KW - POSITRON-EMISSION-TOMOGRAPHY
KW - LEFT-VENTRICULAR FUNCTION
KW - CHRONIC HEART-FAILURE
KW - BLOOD-FLOW
KW - QUANTIFICATION
U2 - 10.1007/s10554-014-0538-1
DO - 10.1007/s10554-014-0538-1
M3 - Article
SN - 1569-5794
VL - 31
SP - 213
EP - 219
JO - International Journal Of Cardiovascular Imaging
JF - International Journal Of Cardiovascular Imaging
IS - 1
ER -