Imaging of the 5-HT2A system: age-, gender-, and Alzheimer's disease-related findings

J Versijpt*, KJ Van Laere, F Dumont, D Decoo, M Vandecapelle, P Santens, [No Value] Goethals, K Audenaert, G Slegers, RA Dierckx, J Korf

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    71 Citations (Scopus)

    Abstract

    Serotonin (5-HT) and more specifically the 5-HT2A receptor is involved in cognitive and non-cognitive behavior and plays an important role in Alzheimer's disease (AD). The objective was to assess the 5-HT2A binding potential (BP) in healthy volunteers and AD with SPECT and I-123-5-I-R91150, a selective radio-iodinated 5-HT2A receptor antagonist. Twenty-six controls and nine AD patients were included. A semiquantitive analysis with normalization on cerebellar uptake provided estimates of BP for 26 cortical regions of interest. An age-related decline of neocortical BP was found (11.6% per decade). Compared to age-matched controls, a generally decreased neocortical BP in AD was found with a significant regional reduction in the orbitofrontal, prefrontal, lateral frontal, cingulate, sensorimotor, parietal inferior, and occipital region. These results are in line with previous postmortem, in vitro, and PET findings. The age-related decline highlights the necessity for matched advanced age study samples. The fact that the 5-HT2A receptor is differentially affected in AD patients has implications for both the etiological basis and therapeutic management of AD. (C) 2002 Elsevier Science Inc. All rights reserved.

    Original languageEnglish
    Article numberPII S0197-4580(02)00137-9
    Pages (from-to)553-561
    Number of pages9
    JournalNeurobiology of Aging
    Volume24
    Issue number4
    Publication statusPublished - 2003

    Keywords

    • serotonin receptor
    • 5-HT2A
    • SPECT
    • I-123-5-I-R91150
    • age
    • gender
    • Alzheimer's disease
    • PHOTON EMISSION TOMOGRAPHY
    • LIVING HUMAN-BRAIN
    • SEROTONIN RECEPTORS
    • MAJOR DEPRESSION
    • I-123 5-I-R91150
    • F-18 SETOPERONE
    • 2A RECEPTORS
    • LATE-LIFE
    • DEMENTIA
    • BINDING

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