IMMUNE AND NEUROIMMUNE ALTERATIONS IN MOOD DISORDERS AND SCHIZOPHRENIA

Roosmarijn C. Drexhage; Karin Weigelt; Nico van Beveren; Dan Cohen; Marjan A. Versnell; Willem A. Nolen; Hemmo A. Drexhage

doi:10.1016/B978-0-12-387718-5.00007-9

IMMUNE AND NEUROIMMUNE ALTERATIONS IN MOOD DISORDERS AND SCHIZOPHRENIA

Roosmarijn C. Drexhage^*, Karin Weigelt, Nico van Beveren, Dan Cohen, Marjan A. Versnell, Willem A. Nolen, Hemmo A. Drexhage

^*Corresponding author for this work

Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE)

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

66 Citations (Scopus)

Abstract

A large number of publications over the past 20 years have indicated that immune system function is altered in schizophrenia and mood disorder patients. This chapter reviews the evidence, which suggests that a proinflammatory state of the cytokine network induces psychopathologic symptoms and may be involved in the pathogenesis and pathophysiology of these major mental illnesses. The authors also present recent data, which relates immune activation to present theories on the influence of activated immune cells in altering brain function. They also focus on the role of the environment in immune activation and on the role of the microbiome and gut flora. Increased understanding of such factors could help in the development of novel treatment strategies and improved clinical management of mental disorders.

Original language	English
Title of host publication	BIOMARKERS OF NEUROLOGICAL AND PSYCHIATRIC DISEASE
Editors	PC Guest, S Bahn
Place of Publication	SAN DIEGO
Publisher	Academic Press
Pages	169-201
Number of pages	33
ISBN (Print)	978-0-12-387718-5
DOIs	https://doi.org/10.1016/B978-0-12-387718-5.00007-9
Publication status	Published - 2011

Publication series

Name	International Review of Neurobiology
Publisher	ELSEVIER ACADEMIC PRESS INC
Volume	101
ISSN (Print)	0074-7742

Keywords

PITUITARY-ADRENAL AXIS
NECROSIS-FACTOR-ALPHA
MONOCYTE CHEMOATTRACTANT PROTEIN-1
INFLAMMATORY RESPONSE SYSTEM
VARIANTS CONFERRING RISK
INCREASED SERUM-LEVELS
BIPOLAR DISORDER
PLASMA-LEVELS
TOXOPLASMA-GONDII
METABOLIC SYNDROME

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Drexhage, R. C., Weigelt, K., van Beveren, N., Cohen, D., Versnell, M. A., Nolen, W. A., & Drexhage, H. A. (2011). IMMUNE AND NEUROIMMUNE ALTERATIONS IN MOOD DISORDERS AND SCHIZOPHRENIA. In PC. Guest, & S. Bahn (Eds.), BIOMARKERS OF NEUROLOGICAL AND PSYCHIATRIC DISEASE (pp. 169-201). (International Review of Neurobiology; Vol. 101). Academic Press. https://doi.org/10.1016/B978-0-12-387718-5.00007-9

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title = "IMMUNE AND NEUROIMMUNE ALTERATIONS IN MOOD DISORDERS AND SCHIZOPHRENIA",

abstract = "A large number of publications over the past 20 years have indicated that immune system function is altered in schizophrenia and mood disorder patients. This chapter reviews the evidence, which suggests that a proinflammatory state of the cytokine network induces psychopathologic symptoms and may be involved in the pathogenesis and pathophysiology of these major mental illnesses. The authors also present recent data, which relates immune activation to present theories on the influence of activated immune cells in altering brain function. They also focus on the role of the environment in immune activation and on the role of the microbiome and gut flora. Increased understanding of such factors could help in the development of novel treatment strategies and improved clinical management of mental disorders.",

keywords = "PITUITARY-ADRENAL AXIS, NECROSIS-FACTOR-ALPHA, MONOCYTE CHEMOATTRACTANT PROTEIN-1, INFLAMMATORY RESPONSE SYSTEM, VARIANTS CONFERRING RISK, INCREASED SERUM-LEVELS, BIPOLAR DISORDER, PLASMA-LEVELS, TOXOPLASMA-GONDII, METABOLIC SYNDROME",

author = "Drexhage, {Roosmarijn C.} and Karin Weigelt and {van Beveren}, Nico and Dan Cohen and Versnell, {Marjan A.} and Nolen, {Willem A.} and Drexhage, {Hemmo A.}",

year = "2011",

doi = "10.1016/B978-0-12-387718-5.00007-9",

language = "English",

isbn = "978-0-12-387718-5",

series = "International Review of Neurobiology",

publisher = "Academic Press",

pages = "169--201",

editor = "PC Guest and S Bahn",

booktitle = "BIOMARKERS OF NEUROLOGICAL AND PSYCHIATRIC DISEASE",

}

Drexhage, RC, Weigelt, K, van Beveren, N, Cohen, D, Versnell, MA, Nolen, WA & Drexhage, HA 2011, IMMUNE AND NEUROIMMUNE ALTERATIONS IN MOOD DISORDERS AND SCHIZOPHRENIA. in PC Guest & S Bahn (eds), BIOMARKERS OF NEUROLOGICAL AND PSYCHIATRIC DISEASE. International Review of Neurobiology, vol. 101, Academic Press, SAN DIEGO, pp. 169-201. https://doi.org/10.1016/B978-0-12-387718-5.00007-9

IMMUNE AND NEUROIMMUNE ALTERATIONS IN MOOD DISORDERS AND SCHIZOPHRENIA. / Drexhage, Roosmarijn C.; Weigelt, Karin; van Beveren, Nico et al.
BIOMARKERS OF NEUROLOGICAL AND PSYCHIATRIC DISEASE. ed. / PC Guest; S Bahn. SAN DIEGO: Academic Press, 2011. p. 169-201 (International Review of Neurobiology; Vol. 101).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

TY - CHAP

T1 - IMMUNE AND NEUROIMMUNE ALTERATIONS IN MOOD DISORDERS AND SCHIZOPHRENIA

AU - Drexhage, Roosmarijn C.

AU - Weigelt, Karin

AU - van Beveren, Nico

AU - Cohen, Dan

AU - Versnell, Marjan A.

AU - Nolen, Willem A.

AU - Drexhage, Hemmo A.

PY - 2011

Y1 - 2011

N2 - A large number of publications over the past 20 years have indicated that immune system function is altered in schizophrenia and mood disorder patients. This chapter reviews the evidence, which suggests that a proinflammatory state of the cytokine network induces psychopathologic symptoms and may be involved in the pathogenesis and pathophysiology of these major mental illnesses. The authors also present recent data, which relates immune activation to present theories on the influence of activated immune cells in altering brain function. They also focus on the role of the environment in immune activation and on the role of the microbiome and gut flora. Increased understanding of such factors could help in the development of novel treatment strategies and improved clinical management of mental disorders.

AB - A large number of publications over the past 20 years have indicated that immune system function is altered in schizophrenia and mood disorder patients. This chapter reviews the evidence, which suggests that a proinflammatory state of the cytokine network induces psychopathologic symptoms and may be involved in the pathogenesis and pathophysiology of these major mental illnesses. The authors also present recent data, which relates immune activation to present theories on the influence of activated immune cells in altering brain function. They also focus on the role of the environment in immune activation and on the role of the microbiome and gut flora. Increased understanding of such factors could help in the development of novel treatment strategies and improved clinical management of mental disorders.

KW - PITUITARY-ADRENAL AXIS

KW - NECROSIS-FACTOR-ALPHA

KW - MONOCYTE CHEMOATTRACTANT PROTEIN-1

KW - INFLAMMATORY RESPONSE SYSTEM

KW - VARIANTS CONFERRING RISK

KW - INCREASED SERUM-LEVELS

KW - BIPOLAR DISORDER

KW - PLASMA-LEVELS

KW - TOXOPLASMA-GONDII

KW - METABOLIC SYNDROME

U2 - 10.1016/B978-0-12-387718-5.00007-9

DO - 10.1016/B978-0-12-387718-5.00007-9

M3 - Chapter

SN - 978-0-12-387718-5

T3 - International Review of Neurobiology

SP - 169

EP - 201

BT - BIOMARKERS OF NEUROLOGICAL AND PSYCHIATRIC DISEASE

A2 - Guest, PC

A2 - Bahn, S

PB - Academic Press

CY - SAN DIEGO

ER -

IMMUNE AND NEUROIMMUNE ALTERATIONS IN MOOD DISORDERS AND SCHIZOPHRENIA

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