TY - JOUR
T1 - Immune homeostasis modulation by hydrogel-guided delivery systems
T2 - a tool for accelerated bone regeneration
AU - Mi, Bobin
AU - Xiong, Yuan
AU - Zha, Kangkang
AU - Cao, Faqi
AU - Zhou, Wu
AU - Abbaszadeh, Samin
AU - Ouyang, Lizhi
AU - Liao, Yuheng
AU - Hu, Weixian
AU - Dai, Guandong
AU - Zhao, Zhiming
AU - Feng, Qian
AU - Shahbazi, Mohammad Ali
AU - Liu, Guohui
N1 - Publisher Copyright:
© 2023 The Royal Society of Chemistry.
PY - 2023/7/31
Y1 - 2023/7/31
N2 - Immune homeostasis is delicately mediated by the dynamic balance between effector immune cells and regulatory immune cells. Local deviations from immune homeostasis in the microenvironment of bone fractures, caused by an increased ratio of effector to regulatory cues, can lead to excessive inflammatory conditions and hinder bone regeneration. Therefore, achieving effective and localized immunomodulation of bone fractures is crucial for successful bone regeneration. Recent research has focused on developing localized and specific immunomodulatory strategies using local hydrogel-based delivery systems. In this review, we aim to emphasize the significant role of immune homeostasis in bone regeneration, explore local hydrogel-based delivery systems, discuss emerging trends in immunomodulation for enhancing bone regeneration, and address the limitations of current delivery strategies along with the challenges of clinical translation.
AB - Immune homeostasis is delicately mediated by the dynamic balance between effector immune cells and regulatory immune cells. Local deviations from immune homeostasis in the microenvironment of bone fractures, caused by an increased ratio of effector to regulatory cues, can lead to excessive inflammatory conditions and hinder bone regeneration. Therefore, achieving effective and localized immunomodulation of bone fractures is crucial for successful bone regeneration. Recent research has focused on developing localized and specific immunomodulatory strategies using local hydrogel-based delivery systems. In this review, we aim to emphasize the significant role of immune homeostasis in bone regeneration, explore local hydrogel-based delivery systems, discuss emerging trends in immunomodulation for enhancing bone regeneration, and address the limitations of current delivery strategies along with the challenges of clinical translation.
UR - https://www.scopus.com/pages/publications/85167519318
U2 - 10.1039/d3bm00544e
DO - 10.1039/d3bm00544e
M3 - Review article
C2 - 37522328
AN - SCOPUS:85167519318
SN - 2047-4830
VL - 11
SP - 6035
EP - 6059
JO - Biomaterials Science
JF - Biomaterials Science
IS - 18
ER -