Immune Response after Surfactant Treatment of Newborn Infants with Respiratory Distress Syndrome

S. Bambang Oetomo, A.F. Bos, L. de Lei, A. Okken, L van Sonderen, HL HALLIDAY, H WALTI

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Abstract

We examined the sera of 68 newborn infants with respiratory distress syndrome; 49 were treated with a natural porcine-derived surfactant preparation and 19 were controls. Serum of the patients was collected before, 3 weeks and 3 months after surfactant treatment. To detect any antibody that had been raised, we applied diluted serum of the babies in an indirect immunoperoxidase staining technique on frozen pig lung tissue specimens. With light microscopy an immune response could be appreciated as a brown reddish deposit in the porcine lung tissue specimens in 4 out of the 49 surfactant-treated and not in the control babies.

Original languageEnglish
Pages (from-to)341-345
Number of pages5
JournalBiology of the neonate
Volume64
Issue number6
DOIs
Publication statusPublished - Dec-1993

Keywords

  • SURFACTANT TREATMENT
  • IMMUNE RESPONSE
  • NEONATAL RESPIRATORY DISTRESS SYNDROME
  • PREMATURE-INFANTS
  • BOVINE SURFACTANT
  • RANDOMIZED TRIAL
  • LUNG SURFACTANT
  • DOUBLE-BLIND
  • MULTICENTER
  • ANTIBODIES
  • REPLACEMENT
  • PROTEINS
  • THERAPY

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