Immunophenotypes of malignant lymphoma centroblastic-centrocytic and malignant lymphoma centrocytic: An immunohistologic study indicating a derivation from different stages of B cell differentiation

Harry Hollema*, Sibrand Poppema

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    27 Citations (Scopus)


    Five cases of intermediate lymphocytic lymphoma (ILL), 13 cases of malignant lymphoma centrocytic (MLCC), and 27 cases of malignant lymphoma centroblastic centrocytic (MLCBCC) were studied morphologically and with the aid of a panel of monoclonal antibodies. The immunophenotypes of ILL and MLCC (IgM+/IgD+, MT1+, CALLA−) indicate a mantle zone or very early follicle center derivation. The immunophenotypes of MLCBCC (IgM+ or IgG/IgA+, MT1−, CALLA+) indicate a “true” follicle center derivation. The morphologic diversity of MLCBCC could not be related to specific immunophenotypes.
    Original languageEnglish
    Pages (from-to)1053-1059
    Number of pages7
    JournalHuman Pathology
    Issue number9
    Publication statusPublished - Sep-1988

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