Impact of a randomized trial on maintenance tocolysis on length of hospital admission of women with threatened preterm labor in The Netherlands

Thomas S. de Lange; Carolien Roos; Kitty W. M. Bloemenkamp; Antoinette C. Bolte; Johannes J. J. Duvekot; Maureen T. M. Franssen; Marjolein Kok; Martijn A. Oudijk; Martina M. Porath; Joris A. M. van der Post; Ben Willem J. Mol

doi:10.1016/j.ejogrb.2014.12.003

Impact of a randomized trial on maintenance tocolysis on length of hospital admission of women with threatened preterm labor in The Netherlands

Thomas S. de Lange, Carolien Roos^*, Kitty W. M. Bloemenkamp, Antoinette C. Bolte, Johannes J. J. Duvekot, Maureen T. M. Franssen, Marjolein Kok, Martijn A. Oudijk, Martina M. Porath, Joris A. M. van der Post, Ben Willem J. Mol

^*Corresponding author for this work

Reproductive Origins of Adult Health and Disease (ROAHD)

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6 Citations (Scopus)

Abstract

Introduction: The APOSTEL-II trial was a multicenter randomized placebo-controlled trial, assessing the effectiveness of maintenance tocolysis with nifedipine. The trial showed maintenance tocolysis not to have an effect on perinatal outcome. Objective of the current study is to evaluate the effect of a negative trial on the length of hospital admission of women with threatened preterm labor.

Materials and methods: We evaluated length of hospital admission of all patients admitted with threatened preterm labor with a gestational age

Results: The mean length of hospital admission was 9.3 days before the start of the trial, 8.4 days during the recruitment period and 8.1 days after the trial was completed. The difference in mean length of hospital admission before and during the recruitment period was significantly different (p <001).

Comments: The length of hospital admission of women with threatened preterm labor is found to be reduced during the recruitment period of the APOSTEL-II trial. This shows that the conduct of a randomized controlled trial itself has the potential to change daily practice. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	8-11
Number of pages	4
Journal	European journal of obstetrics gynecology and reproductive biology
Volume	186
DOIs	https://doi.org/10.1016/j.ejogrb.2014.12.003
Publication status	Published - Mar-2015

Keywords

Admission
Threatened preterm labor
Maintenance tocolysis
NIFEDIPINE
BIRTH

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de Lange, T. S., Roos, C., Bloemenkamp, K. W. M., Bolte, A. C., Duvekot, J. J. J., Franssen, M. T. M., Kok, M., Oudijk, M. A., Porath, M. M., van der Post, J. A. M., & Mol, B. W. J. (2015). Impact of a randomized trial on maintenance tocolysis on length of hospital admission of women with threatened preterm labor in The Netherlands. European journal of obstetrics gynecology and reproductive biology, 186, 8-11. https://doi.org/10.1016/j.ejogrb.2014.12.003

@article{b038b1a1c8e44ff8a92d486cb68201b0,

title = "Impact of a randomized trial on maintenance tocolysis on length of hospital admission of women with threatened preterm labor in The Netherlands",

abstract = "Introduction: The APOSTEL-II trial was a multicenter randomized placebo-controlled trial, assessing the effectiveness of maintenance tocolysis with nifedipine. The trial showed maintenance tocolysis not to have an effect on perinatal outcome. Objective of the current study is to evaluate the effect of a negative trial on the length of hospital admission of women with threatened preterm labor.Materials and methods: We evaluated length of hospital admission of all patients admitted with threatened preterm labor with a gestational ageResults: The mean length of hospital admission was 9.3 days before the start of the trial, 8.4 days during the recruitment period and 8.1 days after the trial was completed. The difference in mean length of hospital admission before and during the recruitment period was significantly different (p <001).Comments: The length of hospital admission of women with threatened preterm labor is found to be reduced during the recruitment period of the APOSTEL-II trial. This shows that the conduct of a randomized controlled trial itself has the potential to change daily practice. (C) 2014 Elsevier Ireland Ltd. All rights reserved.",

keywords = "Admission, Threatened preterm labor, Maintenance tocolysis, NIFEDIPINE, BIRTH",

author = "{de Lange}, {Thomas S.} and Carolien Roos and Bloemenkamp, {Kitty W. M.} and Bolte, {Antoinette C.} and Duvekot, {Johannes J. J.} and Franssen, {Maureen T. M.} and Marjolein Kok and Oudijk, {Martijn A.} and Porath, {Martina M.} and {van der Post}, {Joris A. M.} and Mol, {Ben Willem J.}",

year = "2015",

month = mar,

doi = "10.1016/j.ejogrb.2014.12.003",

language = "English",

volume = "186",

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de Lange, TS, Roos, C, Bloemenkamp, KWM, Bolte, AC, Duvekot, JJJ, Franssen, MTM, Kok, M, Oudijk, MA, Porath, MM, van der Post, JAM & Mol, BWJ 2015, 'Impact of a randomized trial on maintenance tocolysis on length of hospital admission of women with threatened preterm labor in The Netherlands', European journal of obstetrics gynecology and reproductive biology, vol. 186, pp. 8-11. https://doi.org/10.1016/j.ejogrb.2014.12.003

Impact of a randomized trial on maintenance tocolysis on length of hospital admission of women with threatened preterm labor in The Netherlands. / de Lange, Thomas S.; Roos, Carolien; Bloemenkamp, Kitty W. M. et al.
In: European journal of obstetrics gynecology and reproductive biology, Vol. 186, 03.2015, p. 8-11.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Impact of a randomized trial on maintenance tocolysis on length of hospital admission of women with threatened preterm labor in The Netherlands

AU - de Lange, Thomas S.

AU - Roos, Carolien

AU - Bloemenkamp, Kitty W. M.

AU - Bolte, Antoinette C.

AU - Duvekot, Johannes J. J.

AU - Franssen, Maureen T. M.

AU - Kok, Marjolein

AU - Oudijk, Martijn A.

AU - Porath, Martina M.

AU - van der Post, Joris A. M.

AU - Mol, Ben Willem J.

PY - 2015/3

Y1 - 2015/3

N2 - Introduction: The APOSTEL-II trial was a multicenter randomized placebo-controlled trial, assessing the effectiveness of maintenance tocolysis with nifedipine. The trial showed maintenance tocolysis not to have an effect on perinatal outcome. Objective of the current study is to evaluate the effect of a negative trial on the length of hospital admission of women with threatened preterm labor.Materials and methods: We evaluated length of hospital admission of all patients admitted with threatened preterm labor with a gestational ageResults: The mean length of hospital admission was 9.3 days before the start of the trial, 8.4 days during the recruitment period and 8.1 days after the trial was completed. The difference in mean length of hospital admission before and during the recruitment period was significantly different (p <001).Comments: The length of hospital admission of women with threatened preterm labor is found to be reduced during the recruitment period of the APOSTEL-II trial. This shows that the conduct of a randomized controlled trial itself has the potential to change daily practice. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

AB - Introduction: The APOSTEL-II trial was a multicenter randomized placebo-controlled trial, assessing the effectiveness of maintenance tocolysis with nifedipine. The trial showed maintenance tocolysis not to have an effect on perinatal outcome. Objective of the current study is to evaluate the effect of a negative trial on the length of hospital admission of women with threatened preterm labor.Materials and methods: We evaluated length of hospital admission of all patients admitted with threatened preterm labor with a gestational ageResults: The mean length of hospital admission was 9.3 days before the start of the trial, 8.4 days during the recruitment period and 8.1 days after the trial was completed. The difference in mean length of hospital admission before and during the recruitment period was significantly different (p <001).Comments: The length of hospital admission of women with threatened preterm labor is found to be reduced during the recruitment period of the APOSTEL-II trial. This shows that the conduct of a randomized controlled trial itself has the potential to change daily practice. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

KW - Admission

KW - Threatened preterm labor

KW - Maintenance tocolysis

KW - NIFEDIPINE

KW - BIRTH

U2 - 10.1016/j.ejogrb.2014.12.003

DO - 10.1016/j.ejogrb.2014.12.003

M3 - Article

SN - 0301-2115

VL - 186

SP - 8

EP - 11

JO - European journal of obstetrics gynecology and reproductive biology

JF - European journal of obstetrics gynecology and reproductive biology

ER -

Impact of a randomized trial on maintenance tocolysis on length of hospital admission of women with threatened preterm labor in The Netherlands

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