Impact of radiation-induced xerostomia on quality of life after primary radiotherapy among patients with head and neck cancer

Anke Petra Jellema; Ben J. Slotman; Patricia Doornaert; C. Rene Leemans; Johannes A. Langendijk

doi:10.1016/j.ijrobp.2007.04.021

Impact of radiation-induced xerostomia on quality of life after primary radiotherapy among patients with head and neck cancer

Anke Petra Jellema^*
, Ben J. Slotman
, Patricia Doornaert
, C. Rene Leemans
, Johannes A. Langendijk

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

206 Citations (Scopus)

Abstract

Purpose: To investigate the impact of xerostomia on overall quality of life (QoL) outcome and related dimensions among bead and neck cancer patients treated with primary radiotherapy.

Methods and Materials: A total of 288 patients with Stage I-IV disease without distant metastases were included. Late xerostomia according to the Radiation Therapy Oncology Group (RTOG-xerostomia) and QoL (European Organization for Research and Treatment of Cancer QLC-C30) were assessed at baseline and every 6th month from 6 months to 24 months after radiotherapy.

Results: A significant association was found between RTOG-xerostomia and overall QoL outcome (effect size [ES] 0.07, p <0.001). A significant relationship with global QoL, all functioning scales, and fatigue and insomnia was observed. A significant interaction term was present between RTOG-xerostomia and gender and between RTOG-xerostomia and age. In terms of gender, RTOG-xerostomia had a larger impact on overall QoL outcome in women (ES 0.13 for women vs. 0.07 for men). Furthermore, in women ES on individual scales were larger, and a marked worsening was observed with increasing RTOG-xerostomia. No different ES according to age was seen (ES 0.10 for 18-65 years vs. 0.08 for >65 years). An analysis of the impact of RTOG-xerostomia on overall QoL outcome over time showed an increase from 0.09 at 6 months to 0.22 at 24 months. With elapsing time, a worsening was found for these individual scales with increasing RTOG-xerostomia.

Conclusions: The results of this prospective study are the first to show a significant impact of radiation-induced xerostomia on QoL. Although the incidence of Grade >= 2 RTOG-xerostomia decreases with time, its impact on QoL increases. This finding emphasizes the importance of prevention of xerostomia. (C) 2007 Elsevier Inc.

Original language	English
Pages (from-to)	751-760
Number of pages	10
Journal	International Journal of Radiation Oncology Biology Physics
Volume	69
Issue number	3
DOIs	https://doi.org/10.1016/j.ijrobp.2007.04.021
Publication status	Published - 1-Nov-2007
Event	48th Annual Meeting of the American-Society-for-Therapeutic-Radiology-and-Oncology (ASTRO) - , Panama Duration: 5-Nov-2006 → 9-Nov-2006

Keywords

xerostomia
quality of life
radiotherapy
head and neck cancer
PAROTID-GLAND FUNCTION
EUROPEAN-ORGANIZATION
SPARING RADIOTHERAPY
SALIVARY-GLAND
EORTC
THERAPY
VOLUME
QUESTIONNAIRE
PRESERVATION
CHEMOTHERAPY

Access to Document

10.1016/j.ijrobp.2007.04.021

Handle.net

Persistent link

Cite this

@article{a95c9fca1d4f4216802baa188c025aea,

title = "Impact of radiation-induced xerostomia on quality of life after primary radiotherapy among patients with head and neck cancer",

abstract = "Purpose: To investigate the impact of xerostomia on overall quality of life (QoL) outcome and related dimensions among bead and neck cancer patients treated with primary radiotherapy.Methods and Materials: A total of 288 patients with Stage I-IV disease without distant metastases were included. Late xerostomia according to the Radiation Therapy Oncology Group (RTOG-xerostomia) and QoL (European Organization for Research and Treatment of Cancer QLC-C30) were assessed at baseline and every 6th month from 6 months to 24 months after radiotherapy.Results: A significant association was found between RTOG-xerostomia and overall QoL outcome (effect size [ES] 0.07, p <0.001). A significant relationship with global QoL, all functioning scales, and fatigue and insomnia was observed. A significant interaction term was present between RTOG-xerostomia and gender and between RTOG-xerostomia and age. In terms of gender, RTOG-xerostomia had a larger impact on overall QoL outcome in women (ES 0.13 for women vs. 0.07 for men). Furthermore, in women ES on individual scales were larger, and a marked worsening was observed with increasing RTOG-xerostomia. No different ES according to age was seen (ES 0.10 for 18-65 years vs. 0.08 for >65 years). An analysis of the impact of RTOG-xerostomia on overall QoL outcome over time showed an increase from 0.09 at 6 months to 0.22 at 24 months. With elapsing time, a worsening was found for these individual scales with increasing RTOG-xerostomia.Conclusions: The results of this prospective study are the first to show a significant impact of radiation-induced xerostomia on QoL. Although the incidence of Grade >= 2 RTOG-xerostomia decreases with time, its impact on QoL increases. This finding emphasizes the importance of prevention of xerostomia. (C) 2007 Elsevier Inc.",

keywords = "xerostomia, quality of life, radiotherapy, head and neck cancer, PAROTID-GLAND FUNCTION, EUROPEAN-ORGANIZATION, SPARING RADIOTHERAPY, SALIVARY-GLAND, EORTC, THERAPY, VOLUME, QUESTIONNAIRE, PRESERVATION, CHEMOTHERAPY",

author = "Jellema, \{Anke Petra\} and Slotman, \{Ben J.\} and Patricia Doornaert and Leemans, \{C. Rene\} and Langendijk, \{Johannes A.\}",

year = "2007",

month = nov,

day = "1",

doi = "10.1016/j.ijrobp.2007.04.021",

language = "English",

volume = "69",

pages = "751--760",

journal = "International Journal of Radiation Oncology Biology Physics",

issn = "0360-3016",

publisher = "ELSEVIER SCIENCE INC",

number = "3",

note = "48th Annual Meeting of the American-Society-for-Therapeutic-Radiology-and-Oncology (ASTRO) ; Conference date: 05-11-2006 Through 09-11-2006",

}

Impact of radiation-induced xerostomia on quality of life after primary radiotherapy among patients with head and neck cancer. / Jellema, Anke Petra; Slotman, Ben J.; Doornaert, Patricia et al.
In: International Journal of Radiation Oncology Biology Physics, Vol. 69, No. 3, 01.11.2007, p. 751-760.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Impact of radiation-induced xerostomia on quality of life after primary radiotherapy among patients with head and neck cancer

AU - Jellema, Anke Petra

AU - Slotman, Ben J.

AU - Doornaert, Patricia

AU - Leemans, C. Rene

AU - Langendijk, Johannes A.

PY - 2007/11/1

Y1 - 2007/11/1

N2 - Purpose: To investigate the impact of xerostomia on overall quality of life (QoL) outcome and related dimensions among bead and neck cancer patients treated with primary radiotherapy.Methods and Materials: A total of 288 patients with Stage I-IV disease without distant metastases were included. Late xerostomia according to the Radiation Therapy Oncology Group (RTOG-xerostomia) and QoL (European Organization for Research and Treatment of Cancer QLC-C30) were assessed at baseline and every 6th month from 6 months to 24 months after radiotherapy.Results: A significant association was found between RTOG-xerostomia and overall QoL outcome (effect size [ES] 0.07, p <0.001). A significant relationship with global QoL, all functioning scales, and fatigue and insomnia was observed. A significant interaction term was present between RTOG-xerostomia and gender and between RTOG-xerostomia and age. In terms of gender, RTOG-xerostomia had a larger impact on overall QoL outcome in women (ES 0.13 for women vs. 0.07 for men). Furthermore, in women ES on individual scales were larger, and a marked worsening was observed with increasing RTOG-xerostomia. No different ES according to age was seen (ES 0.10 for 18-65 years vs. 0.08 for >65 years). An analysis of the impact of RTOG-xerostomia on overall QoL outcome over time showed an increase from 0.09 at 6 months to 0.22 at 24 months. With elapsing time, a worsening was found for these individual scales with increasing RTOG-xerostomia.Conclusions: The results of this prospective study are the first to show a significant impact of radiation-induced xerostomia on QoL. Although the incidence of Grade >= 2 RTOG-xerostomia decreases with time, its impact on QoL increases. This finding emphasizes the importance of prevention of xerostomia. (C) 2007 Elsevier Inc.

AB - Purpose: To investigate the impact of xerostomia on overall quality of life (QoL) outcome and related dimensions among bead and neck cancer patients treated with primary radiotherapy.Methods and Materials: A total of 288 patients with Stage I-IV disease without distant metastases were included. Late xerostomia according to the Radiation Therapy Oncology Group (RTOG-xerostomia) and QoL (European Organization for Research and Treatment of Cancer QLC-C30) were assessed at baseline and every 6th month from 6 months to 24 months after radiotherapy.Results: A significant association was found between RTOG-xerostomia and overall QoL outcome (effect size [ES] 0.07, p <0.001). A significant relationship with global QoL, all functioning scales, and fatigue and insomnia was observed. A significant interaction term was present between RTOG-xerostomia and gender and between RTOG-xerostomia and age. In terms of gender, RTOG-xerostomia had a larger impact on overall QoL outcome in women (ES 0.13 for women vs. 0.07 for men). Furthermore, in women ES on individual scales were larger, and a marked worsening was observed with increasing RTOG-xerostomia. No different ES according to age was seen (ES 0.10 for 18-65 years vs. 0.08 for >65 years). An analysis of the impact of RTOG-xerostomia on overall QoL outcome over time showed an increase from 0.09 at 6 months to 0.22 at 24 months. With elapsing time, a worsening was found for these individual scales with increasing RTOG-xerostomia.Conclusions: The results of this prospective study are the first to show a significant impact of radiation-induced xerostomia on QoL. Although the incidence of Grade >= 2 RTOG-xerostomia decreases with time, its impact on QoL increases. This finding emphasizes the importance of prevention of xerostomia. (C) 2007 Elsevier Inc.

KW - xerostomia

KW - quality of life

KW - radiotherapy

KW - head and neck cancer

KW - PAROTID-GLAND FUNCTION

KW - EUROPEAN-ORGANIZATION

KW - SPARING RADIOTHERAPY

KW - SALIVARY-GLAND

KW - EORTC

KW - THERAPY

KW - VOLUME

KW - QUESTIONNAIRE

KW - PRESERVATION

KW - CHEMOTHERAPY

U2 - 10.1016/j.ijrobp.2007.04.021

DO - 10.1016/j.ijrobp.2007.04.021

M3 - Article

SN - 0360-3016

VL - 69

SP - 751

EP - 760

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

IS - 3

T2 - 48th Annual Meeting of the American-Society-for-Therapeutic-Radiology-and-Oncology (ASTRO)

Y2 - 5 November 2006 through 9 November 2006

ER -

Impact of radiation-induced xerostomia on quality of life after primary radiotherapy among patients with head and neck cancer

Abstract

Keywords

Access to Document

Handle.net

Fingerprint

Cite this