Implications of antiretroviral resistance on viral fitness

M Nijhuis*, S Deeks, C Boucher

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

158 Citations (Scopus)

Abstract

Treatment of HIV infected patients with antiretroviral drugs often results in the emergence of virus variants with reduced sensitivity to these drugs. However, the viral load often remains partially suppressed below pretherapy levels, which might be explained by a reduced fitness of the drug resistant viral population. This review describes the effects of antiretroviral resistance development on the fitness of the viral population and its clinical implications. Curr Opin Infect Dis 14:23-28. (C) 2001 Lippincott Williams & Wilkins.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalCurrent opinion in infectious diseases
Volume14
Issue number1
Publication statusPublished - Feb-2001

Keywords

  • IMMUNODEFICIENCY-VIRUS TYPE-1
  • HIGH-LEVEL RESISTANCE
  • REVERSE-TRANSCRIPTASE
  • PROTEASE INHIBITORS
  • IN-VIVO
  • REPLICATIVE FITNESS
  • COMBINATION THERAPY
  • DRUG-RESISTANCE
  • POL GENE
  • ZIDOVUDINE

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