Implications of Mitochondrial Dysfunction for the Anesthetic and Perioperative Management: A Case Report of Spinal Fusion, Genetic Confusion, and a Patient's Perspective

Linda S. Aglio*, Brian T. Lockhart, Jeantine E. Lunshof, Christoph S. Nabzdyk

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review


    We describe a patient's personal struggle with a symptom complex consisting of profound muscle weakness requiring pyridostigmine, and metabolic abnormalities suggestive of mitochondrial disease. This included a profound sensitivity to opioids, which in the past caused severe respiratory depression during a prior hospital admission. Interestingly, the patient herself is a professor of ethics in genomic sciences, and she and her medical team thus far have not been able to formally diagnose her with mitochondrial disease. The patient now presented for a multilevel lumbar spine fusion and her hospital course and perspective on her medical odyssey are described here.

    Original languageEnglish
    Pages (from-to)103-106
    Number of pages4
    JournalA & A Practice
    Issue number5
    Publication statusPublished - 1-Mar-2018



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