Improved efficiency of budesonide nebulization using surface-active agents

A.M. Bouwman, M. P. Heijstra, N. C. Schaefer, E. J. Duiverman, P. N. LeSouef, S. G. Devadason*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Abstract

Our aim was to improve the efficiency of nebulised budesonide using surface-active agents. Cationic, anionic, and nonionic detergents were added to commercial budesonide suspension, and the particle size distribution during nebulization was measured using both cascade impaction and laser diffraction. Our results showed that the emitted dose was increased after addition of cationic (P

Original languageEnglish
Pages (from-to)357-363
Number of pages7
JournalDrug Delivery
Volume13
Issue number5
DOIs
Publication statusPublished - 2006

Keywords

  • detergent
  • ionic charge
  • nebulization
  • particle size
  • surfactants
  • PARTICLE-SIZE DISTRIBUTION
  • INHALATION SUSPENSION
  • LUNG SURFACTANT
  • YOUNG-CHILDREN
  • INHALED MASS
  • INFANTS
  • OUTPUT
  • NEBULIZERS
  • ASTHMA
  • DIFFRACTION

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