Improved efficiency of budesonide nebulization using surface-active agents

A.M.  Bouwman; M. P. Heijstra; N. C. Schaefer; E. J. Duiverman; P. N. LeSouef; S. G. Devadason

doi:10.1080/10717540500458862

Improved efficiency of budesonide nebulization using surface-active agents

A.M. Bouwman, M. P. Heijstra, N. C. Schaefer, E. J. Duiverman, P. N. LeSouef, S. G. Devadason^*

^*Corresponding author for this work

Faculty of Medical Sciences/UMCG

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Scopus)

Abstract

Our aim was to improve the efficiency of nebulised budesonide using surface-active agents. Cationic, anionic, and nonionic detergents were added to commercial budesonide suspension, and the particle size distribution during nebulization was measured using both cascade impaction and laser diffraction. Our results showed that the emitted dose was increased after addition of cationic (P

Original language	English
Pages (from-to)	357-363
Number of pages	7
Journal	Drug Delivery
Volume	13
Issue number	5
DOIs	https://doi.org/10.1080/10717540500458862
Publication status	Published - 2006

Keywords

detergent
ionic charge
nebulization
particle size
surfactants
PARTICLE-SIZE DISTRIBUTION
INHALATION SUSPENSION
LUNG SURFACTANT
YOUNG-CHILDREN
INHALED MASS
INFANTS
OUTPUT
NEBULIZERS
ASTHMA
DIFFRACTION

Access to Document

10.1080/10717540500458862

Embargoed Document

Improved Efficiency of Budesonide
Final publisher's version, 365 KB

Cite this

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title = "Improved efficiency of budesonide nebulization using surface-active agents",

abstract = "Our aim was to improve the efficiency of nebulised budesonide using surface-active agents. Cationic, anionic, and nonionic detergents were added to commercial budesonide suspension, and the particle size distribution during nebulization was measured using both cascade impaction and laser diffraction. Our results showed that the emitted dose was increased after addition of cationic (P",

keywords = "detergent, ionic charge, nebulization, particle size, surfactants, PARTICLE-SIZE DISTRIBUTION, INHALATION SUSPENSION, LUNG SURFACTANT, YOUNG-CHILDREN, INHALED MASS, INFANTS, OUTPUT, NEBULIZERS, ASTHMA, DIFFRACTION",

author = "A.M. Bouwman and Heijstra, {M. P.} and Schaefer, {N. C.} and Duiverman, {E. J.} and LeSouef, {P. N.} and Devadason, {S. G.}",

year = "2006",

doi = "10.1080/10717540500458862",

language = "English",

volume = "13",

pages = "357--363",

journal = "Drug Delivery",

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T1 - Improved efficiency of budesonide nebulization using surface-active agents

AU - Bouwman, A.M.

AU - Heijstra, M. P.

AU - Schaefer, N. C.

AU - Duiverman, E. J.

AU - LeSouef, P. N.

AU - Devadason, S. G.

PY - 2006

Y1 - 2006

N2 - Our aim was to improve the efficiency of nebulised budesonide using surface-active agents. Cationic, anionic, and nonionic detergents were added to commercial budesonide suspension, and the particle size distribution during nebulization was measured using both cascade impaction and laser diffraction. Our results showed that the emitted dose was increased after addition of cationic (P

AB - Our aim was to improve the efficiency of nebulised budesonide using surface-active agents. Cationic, anionic, and nonionic detergents were added to commercial budesonide suspension, and the particle size distribution during nebulization was measured using both cascade impaction and laser diffraction. Our results showed that the emitted dose was increased after addition of cationic (P

KW - detergent

KW - ionic charge

KW - nebulization

KW - particle size

KW - surfactants

KW - PARTICLE-SIZE DISTRIBUTION

KW - INHALATION SUSPENSION

KW - LUNG SURFACTANT

KW - YOUNG-CHILDREN

KW - INHALED MASS

KW - INFANTS

KW - OUTPUT

KW - NEBULIZERS

KW - ASTHMA

KW - DIFFRACTION

U2 - 10.1080/10717540500458862

DO - 10.1080/10717540500458862

M3 - Article

VL - 13

SP - 357

EP - 363

JO - Drug Delivery

JF - Drug Delivery

SN - 1071-7544

IS - 5

ER -