Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition

Ruud S Kootte; Evgeni Levin; Jarkko Salojärvi; Loek P Smits; Annick V Hartstra; Shanti D Udayappan; Gerben Hermes; Kristien E Bouter; Annefleur M Koopen; Jens J Holst; Filip K Knop; Ellen E Blaak; Jing Zhao; Hauke Smidt; Amy C Harms; Thomas Hankemeijer; Jacques J G H M Bergman; Hans A Romijn; Frank G Schaap; Steven W M Olde Damink; Mariette T Ackermans; Geesje M Dallinga-Thie; Erwin Zoetendal; Willem M de Vos; Mireille J Serlie; Erik S G Stroes; Albert K Groen; Max Nieuwdorp

doi:10.1016/j.cmet.2017.09.008

Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition

Ruud S Kootte
, Evgeni Levin
, Jarkko Salojärvi
, Loek P Smits
, Annick V Hartstra
, Shanti D Udayappan
, Gerben Hermes
, Kristien E Bouter
, Annefleur M Koopen
, Jens J Holst
, Filip K Knop
, Ellen E Blaak
, Jing Zhao
, Hauke Smidt
, Amy C Harms
, Thomas Hankemeijer
, Jacques J G H M Bergman
, Hans A Romijn
, Frank G Schaap
, Steven W M Olde Damink

Mariette T Ackermans, Geesje M Dallinga-Thie, Erwin Zoetendal, Willem M de Vos, Mireille J Serlie, Erik S G Stroes, Albert K Groen, Max Nieuwdorp

Research output: Contribution to journal › Article › Academic › peer-review

859 Citations (Scopus)

Abstract

The intestinal microbiota has been implicated in insulin resistance, although evidence regarding causality in humans is scarce. We therefore studied the effect of lean donor (allogenic) versus own (autologous) fecal microbiota transplantation (FMT) to male recipients with the metabolic syndrome. Whereas we did not observe metabolic changes at 18 weeks after FMT, insulin sensitivity at 6 weeks after allogenic FMT was significantly improved, accompanied by altered microbiota composition. We also observed changes in plasma metabolites such as γ-aminobutyric acid and show that metabolic response upon allogenic FMT (defined as improved insulin sensitivity 6 weeks after FMT) is dependent on decreased fecal microbial diversity at baseline. In conclusion, the beneficial effects of lean donor FMT on glucose metabolism are associated with changes in intestinal microbiota and plasma metabolites and can be predicted based on baseline fecal microbiota composition.

Original language	English
Pages (from-to)	611-619.e6
Journal	Cell Metabolism
Volume	26
Issue number	4
DOIs	https://doi.org/10.1016/j.cmet.2017.09.008
Publication status	Published - 2017
Externally published	Yes

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Improvement of Insulin Sensitivity after Lean Donor
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Bakker, S. (Creator), Dotinga, A. (Creator), Vonk, J. M. (Creator), Smidt, N. (Creator), Scholtens, S. (Creator), Swertz, M. (Creator), Wijmenga, C. (Creator), Wolffenbutel, B. H. (Creator), Stolk, R. (Creator), van Zon, S. (Creator), Rosmalen, J. (Creator), Postma, D. S. (Creator), de Boer, R. (Creator), Navis, G. (Creator), Slaets, J. (Creator), Ormel, J. (Creator), van Dijk, F. (Creator) & Bolmer, B. (Data Manager), Lifelines, 2006
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Kootte, R. S., Levin, E., Salojärvi, J., Smits, L. P., Hartstra, A. V., Udayappan, S. D., Hermes, G., Bouter, K. E., Koopen, A. M., Holst, J. J., Knop, F. K., Blaak, E. E., Zhao, J., Smidt, H., Harms, A. C., Hankemeijer, T., Bergman, J. J. G. H. M., Romijn, H. A., Schaap, F. G., ... Nieuwdorp, M. (2017). Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition. Cell Metabolism, 26(4), 611-619.e6. https://doi.org/10.1016/j.cmet.2017.09.008

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title = "Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition",

abstract = "The intestinal microbiota has been implicated in insulin resistance, although evidence regarding causality in humans is scarce. We therefore studied the effect of lean donor (allogenic) versus own (autologous) fecal microbiota transplantation (FMT) to male recipients with the metabolic syndrome. Whereas we did not observe metabolic changes at 18 weeks after FMT, insulin sensitivity at 6 weeks after allogenic FMT was significantly improved, accompanied by altered microbiota composition. We also observed changes in plasma metabolites such as γ-aminobutyric acid and show that metabolic response upon allogenic FMT (defined as improved insulin sensitivity 6 weeks after FMT) is dependent on decreased fecal microbial diversity at baseline. In conclusion, the beneficial effects of lean donor FMT on glucose metabolism are associated with changes in intestinal microbiota and plasma metabolites and can be predicted based on baseline fecal microbiota composition.",

keywords = "Journal Article",

author = "Kootte, \{Ruud S\} and Evgeni Levin and Jarkko Saloj{\"a}rvi and Smits, \{Loek P\} and Hartstra, \{Annick V\} and Udayappan, \{Shanti D\} and Gerben Hermes and Bouter, \{Kristien E\} and Koopen, \{Annefleur M\} and Holst, \{Jens J\} and Knop, \{Filip K\} and Blaak, \{Ellen E\} and Jing Zhao and Hauke Smidt and Harms, \{Amy C\} and Thomas Hankemeijer and Bergman, \{Jacques J G H M\} and Romijn, \{Hans A\} and Schaap, \{Frank G\} and \{Olde Damink\}, \{Steven W M\} and Ackermans, \{Mariette T\} and Dallinga-Thie, \{Geesje M\} and Erwin Zoetendal and \{de Vos\}, \{Willem M\} and Serlie, \{Mireille J\} and Stroes, \{Erik S G\} and Groen, \{Albert K\} and Max Nieuwdorp",

year = "2017",

doi = "10.1016/j.cmet.2017.09.008",

language = "English",

volume = "26",

pages = "611--619.e6",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

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Kootte, RS, Levin, E, Salojärvi, J, Smits, LP, Hartstra, AV, Udayappan, SD, Hermes, G, Bouter, KE, Koopen, AM, Holst, JJ, Knop, FK, Blaak, EE, Zhao, J, Smidt, H, Harms, AC, Hankemeijer, T, Bergman, JJGHM, Romijn, HA, Schaap, FG, Olde Damink, SWM, Ackermans, MT, Dallinga-Thie, GM, Zoetendal, E, de Vos, WM, Serlie, MJ, Stroes, ESG, Groen, AK & Nieuwdorp, M 2017, 'Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition', Cell Metabolism, vol. 26, no. 4, pp. 611-619.e6. https://doi.org/10.1016/j.cmet.2017.09.008

TY - JOUR

T1 - Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition

AU - Kootte, Ruud S

AU - Levin, Evgeni

AU - Salojärvi, Jarkko

AU - Smits, Loek P

AU - Hartstra, Annick V

AU - Udayappan, Shanti D

AU - Hermes, Gerben

AU - Bouter, Kristien E

AU - Koopen, Annefleur M

AU - Holst, Jens J

AU - Knop, Filip K

AU - Blaak, Ellen E

AU - Zhao, Jing

AU - Smidt, Hauke

AU - Harms, Amy C

AU - Hankemeijer, Thomas

AU - Bergman, Jacques J G H M

AU - Romijn, Hans A

AU - Schaap, Frank G

AU - Olde Damink, Steven W M

AU - Ackermans, Mariette T

AU - Dallinga-Thie, Geesje M

AU - Zoetendal, Erwin

AU - de Vos, Willem M

AU - Serlie, Mireille J

AU - Stroes, Erik S G

AU - Groen, Albert K

AU - Nieuwdorp, Max

PY - 2017

Y1 - 2017

N2 - The intestinal microbiota has been implicated in insulin resistance, although evidence regarding causality in humans is scarce. We therefore studied the effect of lean donor (allogenic) versus own (autologous) fecal microbiota transplantation (FMT) to male recipients with the metabolic syndrome. Whereas we did not observe metabolic changes at 18 weeks after FMT, insulin sensitivity at 6 weeks after allogenic FMT was significantly improved, accompanied by altered microbiota composition. We also observed changes in plasma metabolites such as γ-aminobutyric acid and show that metabolic response upon allogenic FMT (defined as improved insulin sensitivity 6 weeks after FMT) is dependent on decreased fecal microbial diversity at baseline. In conclusion, the beneficial effects of lean donor FMT on glucose metabolism are associated with changes in intestinal microbiota and plasma metabolites and can be predicted based on baseline fecal microbiota composition.

AB - The intestinal microbiota has been implicated in insulin resistance, although evidence regarding causality in humans is scarce. We therefore studied the effect of lean donor (allogenic) versus own (autologous) fecal microbiota transplantation (FMT) to male recipients with the metabolic syndrome. Whereas we did not observe metabolic changes at 18 weeks after FMT, insulin sensitivity at 6 weeks after allogenic FMT was significantly improved, accompanied by altered microbiota composition. We also observed changes in plasma metabolites such as γ-aminobutyric acid and show that metabolic response upon allogenic FMT (defined as improved insulin sensitivity 6 weeks after FMT) is dependent on decreased fecal microbial diversity at baseline. In conclusion, the beneficial effects of lean donor FMT on glucose metabolism are associated with changes in intestinal microbiota and plasma metabolites and can be predicted based on baseline fecal microbiota composition.

KW - Journal Article

U2 - 10.1016/j.cmet.2017.09.008

DO - 10.1016/j.cmet.2017.09.008

M3 - Article

C2 - 28978426

SN - 1550-4131

VL - 26

SP - 611-619.e6

JO - Cell Metabolism

JF - Cell Metabolism

IS - 4

ER -

Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition

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