Improvement of Sodium Status to Optimize the Efficacy of Renin-Angiotensin System Blockade

Gozewijn D. Laverman; Gerjan Navis

doi:10.1007/s11906-011-0234-7

Improvement of Sodium Status to Optimize the Efficacy of Renin-Angiotensin System Blockade

Gozewijn D. Laverman, Gerjan Navis^*

^*Corresponding author for this work

Groningen Kidney Center (GKC)

Research output: Contribution to journal › Editorial › Academic › peer-review

2 Citations (Scopus)

Abstract

Blockade of the renin-angiotensin-aldosterone system (RAAS) offers superior renoprotection in the treatment of patients with hypertension, but the efficacy of RAAS inhibition strongly depends on sodium status, presumably in relation to extracellular volume status. Because assessing volume status by physical examination is challenging, 24-hour urine collection and NT-proBNP levels are useful tools for guiding volume management and achieving sodium status targets.

Original language	English
Pages (from-to)	397-399
Number of pages	3
Journal	Current Hypertension Reports
Volume	13
Issue number	6
DOIs	https://doi.org/10.1007/s11906-011-0234-7
Publication status	Published - Dec-2011

Keywords

Hypertension
Chronic kidney disease
Blood pressure
Therapy
Renoprotection
Sodium
Renin-angiotensin system
Renin-angiotensin-aldosterone system
RAAS blockade
N-terminal pro-brain natriuretic peptide
NT-proBNP
24-hour urine collection
Extracellular volume

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@article{949f904ecf3f486a8656a243ff7e6a85,

title = "Improvement of Sodium Status to Optimize the Efficacy of Renin-Angiotensin System Blockade",

abstract = "Blockade of the renin-angiotensin-aldosterone system (RAAS) offers superior renoprotection in the treatment of patients with hypertension, but the efficacy of RAAS inhibition strongly depends on sodium status, presumably in relation to extracellular volume status. Because assessing volume status by physical examination is challenging, 24-hour urine collection and NT-proBNP levels are useful tools for guiding volume management and achieving sodium status targets.",

keywords = "Hypertension, Chronic kidney disease, Blood pressure, Therapy, Renoprotection, Sodium, Renin-angiotensin system, Renin-angiotensin-aldosterone system, RAAS blockade, N-terminal pro-brain natriuretic peptide, NT-proBNP, 24-hour urine collection, Extracellular volume",

author = "Laverman, {Gozewijn D.} and Gerjan Navis",

year = "2011",

month = dec,

doi = "10.1007/s11906-011-0234-7",

language = "English",

volume = "13",

pages = "397--399",

journal = "Current Hypertension Reports",

issn = "1522-6417",

publisher = "Springer",

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TY - JOUR

T1 - Improvement of Sodium Status to Optimize the Efficacy of Renin-Angiotensin System Blockade

AU - Laverman, Gozewijn D.

AU - Navis, Gerjan

PY - 2011/12

Y1 - 2011/12

N2 - Blockade of the renin-angiotensin-aldosterone system (RAAS) offers superior renoprotection in the treatment of patients with hypertension, but the efficacy of RAAS inhibition strongly depends on sodium status, presumably in relation to extracellular volume status. Because assessing volume status by physical examination is challenging, 24-hour urine collection and NT-proBNP levels are useful tools for guiding volume management and achieving sodium status targets.

AB - Blockade of the renin-angiotensin-aldosterone system (RAAS) offers superior renoprotection in the treatment of patients with hypertension, but the efficacy of RAAS inhibition strongly depends on sodium status, presumably in relation to extracellular volume status. Because assessing volume status by physical examination is challenging, 24-hour urine collection and NT-proBNP levels are useful tools for guiding volume management and achieving sodium status targets.

KW - Hypertension

KW - Chronic kidney disease

KW - Blood pressure

KW - Therapy

KW - Renoprotection

KW - Sodium

KW - Renin-angiotensin system

KW - Renin-angiotensin-aldosterone system

KW - RAAS blockade

KW - N-terminal pro-brain natriuretic peptide

KW - NT-proBNP

KW - 24-hour urine collection

KW - Extracellular volume

U2 - 10.1007/s11906-011-0234-7

DO - 10.1007/s11906-011-0234-7

M3 - Editorial

SN - 1522-6417

VL - 13

SP - 397

EP - 399

JO - Current Hypertension Reports

JF - Current Hypertension Reports

IS - 6

ER -

Improvement of Sodium Status to Optimize the Efficacy of Renin-Angiotensin System Blockade

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Keywords

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